The lower respiratory tract infections are a prime cause of morbidity and mortality in our country. A hospital based cross sectional study was fulfilled with an objective to study the bacterial pathogens isolated and susceptibility pattern from patients of lower respiratory tract infections. Methods: Overall 826 lower respiratory specimens such as sputum, endotracheal aspirates, bronchial aspirate and pleural fluid were cultured aerobically using standard microbiological technique as per Clinical Laboratory Standard Institute guidelines. Results: Out of 826 lower respiratory specimens, 523(63.3%) bacterial pathogens were recovered. Streptococcus pyogenes (65.8%) was the commonest isolate and increase isolation rate was observed in the male 291(55.64%) of 60-79 years age groups. Most of the pathogens showed sensitive to macrolides and aminoglycoisides, however, Streptococcus pyogenes and Staphylococcus aureus were most susceptible to tetracycline 262(75.9%) and azithromycin 53(73.6%). In case of Pseudomonas aeruginosa were sensitive to amikacin 22(64.7%) while Acinetobactor baumani were found sensitive to amikacin 16(80%) and Klebsiella pneumoniae was sensitive to penicillin 37(71.1%). Conclusions: For effective treatment of typical bacterial lower respiratory tract infections, bacterial culture and antibiotic sensitivity testing are required.

Keywords : Lower Respiratory Tract Infections, Bacterial Pathogens, Antibiotic sensitivity