Authors : Dr. Karamo Toure; Ahmadou Sadio Diallo; Yacouba Konate; Cilvin Mamy; Rachel Jamison; Sounounou Diallo; Mamadou Keita; Mamadou Oury Diallo; Tenin Conde; Ibrahima Sory Keita

Volume/Issue : Volume 11 - 2026, Issue 3 - March

Google Scholar : https://tinyurl.com/y8fwfvw4

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DOI : https://doi.org/10.38124/ijisrt/26mar373

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Abstract : Sickle cell disease is a clinically recessive, biologically co-dominant, autosomal dominant hereditary disorder characterized by the presence of an abnormal hemoglobin called hemoglobin S in red blood cells. This hemoglobin S is responsible for the sickling of red blood cells under hypoxia. Given the existing prevalence of sickle cell disease in the Republic of Guinea, which is 11%, this hereditary disease is very poorly understood by the population, yet it constitutes a real public health problem affecting all age groups, sexes, and socioeconomic backgrounds. To achieve our objective, we conducted the following tests: The Immuno Chromatographic Hemotype SC method, performed on 202 patients seen at the laboratory, revealed 78 positive cases, or 39%. The most represented phenotype was homozygous sickle cell disease (85), with 46 cases (59%), followed by sickle cell trait with 32 cases (41%). 90% of patients Patients with sickle cell disease had low hemoglobin levels; leukocytosis was observed in 76%, followed by lymphocytosis in 26% of patients; monocytosis in 9%; eosinophilia in 9%; neutrophilia in 9%; and basophilia in 2%. A hematological profile of children with sickle cell disease was performed. Our study showed us that sickle cell disease is a significant public health problem in the Republic of Guinea, particularly in the Dubréka prefecture.

Keywords : Sickle Cell Disease, Red Blood Cell Sickling, Hereditary Disease, Hemoglobin S.

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