Objectives: To study the prevalence of p53 in
serous ovarian carcinoma, and its association with grade of
the tumor and response to platinum-based chemotherapy.
Methods: It was an analytical study with a quantitative
correlational study design. Convenience non-probability
sampling method was used to enroll 40 patients. Their
tumor grades, p53 status and response to chemotherapy
were measured. Then correlation of p53 with both these
parameters was identified.
Results: Out of the 40 patients enrolled, 34 (85%) had high
grade serous carcinoma while 6 (15%) patients had low
grade disease. They presented mostly with Stage III i.e
67.5% followed by stage IV i.e 27.5%. Complete response
to chemotherapy was seen in 4% of the patients, whereas
50% patients exhibited partial response. For correlation of
p53 and grade, chi square test was used. The p value was
0.03 and therefore significant. For chemotherapy response
chi square was used and turned out to be 0.05 and was also
significant. The regression analysis was run and the “R”
coefficient for clinical response was 0.17. The goodness of
fit test for this regression model is 0.447. The estimated coefficient of wild type p53 was 1.692 keeping the other
category “mutant” as reference category shows that there
is positive relation of wild type and worst response of
chemotherapy and more chances to “no response/stable” in
“wild type” as compared to “mutant” cases. The p-value
was significant i.e (≤0.05) for all response elements.
Conclusions: p53 positive ovarian serous carcinomas are
more prevalent in our patient population and there was a
significant relation between p53 positivity and high tumor
grade. Also, p53 positive tumors had aggressive disease
Keywords : p53; serous ovarian carcinoma; platinum chemotherapy; response.