Authors :
Dr.Dikchhya Khanal; Dr. Den Prasad Acharya; Dr. Soni Shrestha; Dr. Sanjay Shrestha; Dr. Nanda Kishwor Chaudhary
Volume/Issue :
Volume 6 - 2021, Issue 7 - July
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3g94e6s
Abstract :
Introduction: Hypertensive disorders in
pregnancy contribute significantly to the maternal
mortality, premature birth, intrauterine growth
retardation and perinatal mortality. Objectives: This
study is done to determine if microalbuminuria can be
used as a predictive marker of pregnancy induced
hypertension (PIH) and adverse pregnancy and neonatal
outcomes. Materials and Methods: This study was
hospital based longitudinal observational done in
pregnant women attending antenatal clinic in B.P.
Koirala Institute of Health Sciences for a period of 1 year
from January, 2017 to January, 2019. This study involved
total of 504 women of gestational age 24-28 weeks, were
evaluated for microalbuminuria, defined by spot urine
albumin creatinine ratio 30-300 mg/g (Kidney Disease
Improving Global Outcomes guidelines) and followed till
discharge after delivery. Development of PIH and both
maternal and fetal outcome were recorded. Results: Of
the 504 patients pregnant women enrolled in our study, 89
(17.7%) had microalbuminuria. The rate of development
of PIH was significantly higher in microalbuminuric
women compared to non microalbuminuric (p <0.05). The
Sensitivity, Specificity, Positive Predictive Value and
Negative Predictive Value of micro-albuminuria in
predicting occurrence of PIH during Pregnancy was
found to be 42.86%, 84.22%, 16.85% and 95.18%
respectively. Conclusion: The absence of
microalbuminuria was highly specific for predicting
nonoccurrence of PIH during the pregnancy. However,
microalbuminuria had low sensitivity for the screening of
PIH and hence poor predictive value.
Keywords :
Hypertension, Microalbuminuria, Pregnancy
Introduction: Hypertensive disorders in
pregnancy contribute significantly to the maternal
mortality, premature birth, intrauterine growth
retardation and perinatal mortality. Objectives: This
study is done to determine if microalbuminuria can be
used as a predictive marker of pregnancy induced
hypertension (PIH) and adverse pregnancy and neonatal
outcomes. Materials and Methods: This study was
hospital based longitudinal observational done in
pregnant women attending antenatal clinic in B.P.
Koirala Institute of Health Sciences for a period of 1 year
from January, 2017 to January, 2019. This study involved
total of 504 women of gestational age 24-28 weeks, were
evaluated for microalbuminuria, defined by spot urine
albumin creatinine ratio 30-300 mg/g (Kidney Disease
Improving Global Outcomes guidelines) and followed till
discharge after delivery. Development of PIH and both
maternal and fetal outcome were recorded. Results: Of
the 504 patients pregnant women enrolled in our study, 89
(17.7%) had microalbuminuria. The rate of development
of PIH was significantly higher in microalbuminuric
women compared to non microalbuminuric (p <0.05). The
Sensitivity, Specificity, Positive Predictive Value and
Negative Predictive Value of micro-albuminuria in
predicting occurrence of PIH during Pregnancy was
found to be 42.86%, 84.22%, 16.85% and 95.18%
respectively. Conclusion: The absence of
microalbuminuria was highly specific for predicting
nonoccurrence of PIH during the pregnancy. However,
microalbuminuria had low sensitivity for the screening of
PIH and hence poor predictive value.
Keywords :
Hypertension, Microalbuminuria, Pregnancy
