Authors :
Ahmed Hamdi Abdulgafar Khalfalla; Dr. Mohamed Hafiz Salim
Volume/Issue :
Volume 8 - 2023, Issue 2 - February
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3YVkqLS
DOI :
https://doi.org/10.5281/zenodo.7743447
Abstract :
Anti-Müllerian hormone (AMH) is a dimeric glycoprotein and a member of the
transforming growth factor (TGF-β) family of growth and differentiation factors. AMH is a product
of the granulosa cells from the pre-antral and small antral follicles. It acts as a gate keeper of small
growing follicles, limiting follicular growth initiation, and subsequently oestradiol production from
small antral follicles prior to selection. AMH is used as an endocrine marker for ovarian aging in
normogonadotropic and anovulatory infertile women. Due to the prevalence of infertilitywhich is a
neglected issue, particularly in poorer nations, substantial study is required.
Objective: To determine the prevalence of female infertility based on Anti -Müllerian hormone level
to correlate between anti-müllerian hormone, follicle stimulating hormone and Estradiol levels. To
assess the correlation between age of female and levels of anti-müllerian hormone.
Methods: This study was done as a facility-basedRetrospective, descriptive study design, at Royal
Care international hospital, with a number of patients who underwent ICSI for the fertility centre.
Results: For the type of infertility 67 are having primary infertility (58.3%), 48 have a secondary one
(41.7%), for the FSH level 60 have a high level (52.2%), 54 have a normal level (47%), 1 has a low
level (0.9%), for the AMH level 114 have a low one (99.1%), 1 has a normal level (0.9%).For the
number of the previous ICSI attempts 71 had none (61.7%), 20 had one (17.4%), 13 had 2 (11.3%), 5
had 5 (4.3%), 4 had 3 (3.5%), 2 had four times (1.7%), for the outcome of previous ICSI 107 had 0
(negative) (93%), 8 had one (0.7%), for the protocol for ovarian stimulation 102 got HMG (88.7%), 9
got FSH (7.8%), 4 had natural cycle (3.5%), for the number of follicles produced 96 had 1-3 (83.5%)
follicles, 18 had 4-6 (15.7%) follicles, 1 had from 7-10 (0.9%) follicles.
Conclusion: In conclusion 115 couples presented to the Fertility Centre of Royal care international
hospital in the study period. Respectively 58% had primary infertility and 42% had secondary
infertility. In summary the study found no correlation between age and AMH, and no correlation
between AMH, FSH and estradiol levels. On the other hand, a strong correlation between AMH and
number of oocytes produced. Moreover, a strong correlation between AMH and success rates of ICSI
was established. As so concurring with international studies in addition of being a strong indicator of
premature ovarian failure.
Keywords :
AMH, Infertility, ICSI.
Anti-Müllerian hormone (AMH) is a dimeric glycoprotein and a member of the
transforming growth factor (TGF-β) family of growth and differentiation factors. AMH is a product
of the granulosa cells from the pre-antral and small antral follicles. It acts as a gate keeper of small
growing follicles, limiting follicular growth initiation, and subsequently oestradiol production from
small antral follicles prior to selection. AMH is used as an endocrine marker for ovarian aging in
normogonadotropic and anovulatory infertile women. Due to the prevalence of infertilitywhich is a
neglected issue, particularly in poorer nations, substantial study is required.
Objective: To determine the prevalence of female infertility based on Anti -Müllerian hormone level
to correlate between anti-müllerian hormone, follicle stimulating hormone and Estradiol levels. To
assess the correlation between age of female and levels of anti-müllerian hormone.
Methods: This study was done as a facility-basedRetrospective, descriptive study design, at Royal
Care international hospital, with a number of patients who underwent ICSI for the fertility centre.
Results: For the type of infertility 67 are having primary infertility (58.3%), 48 have a secondary one
(41.7%), for the FSH level 60 have a high level (52.2%), 54 have a normal level (47%), 1 has a low
level (0.9%), for the AMH level 114 have a low one (99.1%), 1 has a normal level (0.9%).For the
number of the previous ICSI attempts 71 had none (61.7%), 20 had one (17.4%), 13 had 2 (11.3%), 5
had 5 (4.3%), 4 had 3 (3.5%), 2 had four times (1.7%), for the outcome of previous ICSI 107 had 0
(negative) (93%), 8 had one (0.7%), for the protocol for ovarian stimulation 102 got HMG (88.7%), 9
got FSH (7.8%), 4 had natural cycle (3.5%), for the number of follicles produced 96 had 1-3 (83.5%)
follicles, 18 had 4-6 (15.7%) follicles, 1 had from 7-10 (0.9%) follicles.
Conclusion: In conclusion 115 couples presented to the Fertility Centre of Royal care international
hospital in the study period. Respectively 58% had primary infertility and 42% had secondary
infertility. In summary the study found no correlation between age and AMH, and no correlation
between AMH, FSH and estradiol levels. On the other hand, a strong correlation between AMH and
number of oocytes produced. Moreover, a strong correlation between AMH and success rates of ICSI
was established. As so concurring with international studies in addition of being a strong indicator of
premature ovarian failure.
Keywords :
AMH, Infertility, ICSI.
