Authors :
Toscanini Metshak Mark; Wuyep Cyril Yilyok
Volume/Issue :
Volume 7 - 2022, Issue 12 - December
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3iFLYGp
DOI :
https://doi.org/10.5281/zenodo.7547313
Abstract :
This study aimed to determine the effects of
Diminazene, Levamisole, and Vitamin A on treating
trypanosomiasis in West African Dwarf (WAD) sheep
experimentally infected with Trypanosoma brucei.
Twenty-four (24) adult WAD sheep of mixed sexes were
acclimatized for two months and treated with Albendazole,
Ivermectin, Tick and Flea Powder, and long-acting
Oxytetracycline. The animals were confirmed negative for
trypanosomiasis and brucellosis. They were then infected
with Trypanosoma brucei and treated with Diminazene
Aceturate, Levamisole, and Vitamin A two weeks after the
infection. Parasitemia was established on the 4th day and
was evident in all the infected animals six days postinfection. Reduced Total White Blood Cell count of treated
animals did not affect clinical signs, clearance of parasites
from the bloodstream, or antibody titers to Brucella
abortus. In addition, the study also monitored rectal
temperature and body weight changes. The data showed
that using immunomodulators to treat West African
Dwarf sheep infected with Trypanosoma brucei
significantly increased the erythrocyte indices (PCV, Hb,
and RBCs). Reduced Total White Blood Cell count of
treated animals did not affect clinical signs, the clearance
of parasites from the bloodstream, or antibody titers to
brucella abortus antigen. High titres of Brucella abortus
antibody recorded in all vaccinated animals up to the last
week of the study indicate that trypanosomiasis did not
suppress antibody production in these animals. A
mortality rate of 25% was recorded in groups two, three,
and five during the second week and 33% in group five
during the third week. Death first occurred as early as two
weeks post-infection in groups two, three, and five. The
study concluded that Diminazene Aceturate, vitamin A,
Levamisole, or a combination of Diminazene Aceturate,
vitamin A, and Levamisole should be used to treat ovine
trypanosomiasis.
Keywords :
Diminazane Aceturate; Trypanosomiasis; Immunomodulators; West African Dwarf Sheep; Levamisole;Vitamin A.
This study aimed to determine the effects of
Diminazene, Levamisole, and Vitamin A on treating
trypanosomiasis in West African Dwarf (WAD) sheep
experimentally infected with Trypanosoma brucei.
Twenty-four (24) adult WAD sheep of mixed sexes were
acclimatized for two months and treated with Albendazole,
Ivermectin, Tick and Flea Powder, and long-acting
Oxytetracycline. The animals were confirmed negative for
trypanosomiasis and brucellosis. They were then infected
with Trypanosoma brucei and treated with Diminazene
Aceturate, Levamisole, and Vitamin A two weeks after the
infection. Parasitemia was established on the 4th day and
was evident in all the infected animals six days postinfection. Reduced Total White Blood Cell count of treated
animals did not affect clinical signs, clearance of parasites
from the bloodstream, or antibody titers to Brucella
abortus. In addition, the study also monitored rectal
temperature and body weight changes. The data showed
that using immunomodulators to treat West African
Dwarf sheep infected with Trypanosoma brucei
significantly increased the erythrocyte indices (PCV, Hb,
and RBCs). Reduced Total White Blood Cell count of
treated animals did not affect clinical signs, the clearance
of parasites from the bloodstream, or antibody titers to
brucella abortus antigen. High titres of Brucella abortus
antibody recorded in all vaccinated animals up to the last
week of the study indicate that trypanosomiasis did not
suppress antibody production in these animals. A
mortality rate of 25% was recorded in groups two, three,
and five during the second week and 33% in group five
during the third week. Death first occurred as early as two
weeks post-infection in groups two, three, and five. The
study concluded that Diminazene Aceturate, vitamin A,
Levamisole, or a combination of Diminazene Aceturate,
vitamin A, and Levamisole should be used to treat ovine
trypanosomiasis.
Keywords :
Diminazane Aceturate; Trypanosomiasis; Immunomodulators; West African Dwarf Sheep; Levamisole;Vitamin A.
