Background: Mobile phones have revolutionized our lives and have become a need in today's life.However, for some people, they could be a source of stress. Nomophobia is a psychological condition in which individuals experience fear or anxiety if they do not have their mobile phones. The study objectiveswere to assess the levels of nomophobia in youth in relation to their demographic characteristics, to assess the correlation of nomophobia with personality traits; and to determine the predictive influence of personality traits on nomophobia. Methods: This descriptive, cross-sectional study was conducted at Riphah International University from March to October 2022. The sample size of 784 participants was raised using the convenience sampling technique. Two validated questionnaires, the 20-item Nomophobia Questionnaire (NMP-Q) and the 44-item Big Five Inventory (BFI) were circulated via Google form and analyzed using SPSS version 26.