Authors :
Abara, Priscilla. Nkeonye; Ibeh, Olusola Olubunmi; Adjeroh, Lawrencia Anayochukwu; Ubah, VenatiusChiamaka Steve
Volume/Issue :
Volume 7 - 2022, Issue 5 - May
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/38M48Ba
Abstract :
Healthy male albino wistar rats
(Rattusnorvegicus) were exposedto oral administration of
0.2ml of Nopest®
(DDVP) pesticide once daily for 28
consecutive days at increasing concentration of 0.75, 1.5
and 3.0mg/ml to ascertain possible oxidative stress and
toxic effects on the liver of the animals exposed with the
different concentrations of the pesticide. There was
significant increase (p<0.05) in the body weight for all
the weeks of exposure and for all the groups as
compared to the control group except at week four
(101.4±5.51),(122.6±14.3) and (161.0±19.75) for group
A,B, and C respectively. The liver function analysis was
conducted to determine the level of change in Alanine
Aminotransferase (ALT), Aspartate Aminotransferase
(AST) and Alkaline Phosphatase (ALP). Analysis was
also conducted for antioxidant enzymes: superoxide
dismutase (SOD), glutathione (GSH), ascorbic acid (AA),
and Malondialdehyde (MDA) in order to determine
oxidative stress. There was significant increase in the
levels of the antioxidants (p<0.05) which suggested that
oxidative stress occurred in the exposed rats.
Keywords :
oxidative stress, non-target organism, pesticide
Healthy male albino wistar rats
(Rattusnorvegicus) were exposedto oral administration of
0.2ml of Nopest®
(DDVP) pesticide once daily for 28
consecutive days at increasing concentration of 0.75, 1.5
and 3.0mg/ml to ascertain possible oxidative stress and
toxic effects on the liver of the animals exposed with the
different concentrations of the pesticide. There was
significant increase (p<0.05) in the body weight for all
the weeks of exposure and for all the groups as
compared to the control group except at week four
(101.4±5.51),(122.6±14.3) and (161.0±19.75) for group
A,B, and C respectively. The liver function analysis was
conducted to determine the level of change in Alanine
Aminotransferase (ALT), Aspartate Aminotransferase
(AST) and Alkaline Phosphatase (ALP). Analysis was
also conducted for antioxidant enzymes: superoxide
dismutase (SOD), glutathione (GSH), ascorbic acid (AA),
and Malondialdehyde (MDA) in order to determine
oxidative stress. There was significant increase in the
levels of the antioxidants (p<0.05) which suggested that
oxidative stress occurred in the exposed rats.
Keywords :
oxidative stress, non-target organism, pesticide
