Authors : Anurag Pathak; Moh Faijan; Mohd Adil Tahseen

Volume/Issue : Volume 9 - 2024, Issue 11 - November

Google Scholar : https://tinyurl.com/4hckjt82

Scribd : https://tinyurl.com/y4rp42hv

DOI : https://doi.org/10.38124/ijisrt/IJISRT24NOV049

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : As newly identified phytochemicals increase, studies on their potential medicinal applications in biological contexts will be updated. Nevertheless, these chemicals' limited solubility and susceptibility to degradation limit their use in medicinal and food applications. Currently, learning more about vesicular drug delivery methods may aid in enhancing these features. Because of their exceptional trapping capability, safety, and biocompatibility, vesicles have been demonstrated to be extremely promising delivery methods for a variety of beneficial phytochemicals at a cellular level. Phytosomes, a kind of vesicular drug carrier, combine phytochemicals with phospholipids to produce a complex that enhances compound stability overall and improves the absorption and bioavailability of bioactive compounds. One of the newest, smaller-sized lipid-based vesicles to increase the transport of plant- based nutraceuticals is the nano-phytosome. To guarantee a good safety profile and fulfill repeatability requirements, physical measurements that provide details on the dynamics of release and formulation stability must be thoroughly analyzed. Although there is presently not enough data from clinical trials to make judgments about the biological activities of specific preparations, the overall strength of the evidence supporting these formulations is positive and encourages more study in this area. Clinical trials on standardized products that demonstrate greater effectiveness than unformulated components or extracts will be essential in the future to raise awareness of these technologies.

Keywords : Phytochemicals, Phytosomes, Vesicular drug carrier, Clinical trials.

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