Authors :
Dasari Mercy Leona; Areboina Lavanya
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/yc4rtvy8
Scribd :
https://tinyurl.com/tb323yhu
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY506
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Pharmacogenomics studies how genetics
affects how drugs affect the human body. The terms
genomics and pharmacology are the sources of the field's
name, which represents the intersection of genetics and
medicine. The discovery of the laws of heredity in 1866
marked the beginning of the area of pharmacogenetics
(PGx). The FDA has established PGx testing
recommendations, so whenever these 250+ drugs are
being reviewed, testing should be considered. Physicians
in the fields of pain management, mental health, and
cardiovascular health are among those who provide PGx
recommendations. Antidepressant medications offer
several therapeutic options that are similar, which makes
them a prime candidate for the use of PGx. It makes sense
that pharmaceutical companies are hesitant to use
pharmacogenomics in clinical investigations given its
relative youth. Clinical trials and pharmacogenomic
testing together have many advantages. Finding
populations with risk factors unrelated to the medication
itself may also be facilitated by pharmacogenetics. Oral
anticoagulants and chemotherapy treatment regimens are
now recommended based on a patient's pharmacogenetic
condition. When it comes to patient dosing,
pharmacogenetic techniques are gradually replacing the
traditional method of depending solely on trial and error.
The present therapeutic application of pharmacogenetics
can also be applied to drug research and development.
Keywords :
Pharmacogenetics, Single Nucleotide Polymorphisms, Adverse Drug Events, Pharmaceutical.
References :
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- Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature [Internet]. 2004;429(6990):464–8.
- Pirmohamed M. Pharmacogenetics: past, present and future. Drug Discov Today [Internet]. 2011;16(19–20):852–61.
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- Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui C-H, Stein CM, et al. Clinical pharmacogenetics implementation consortium guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update. Clin Pharmacol Ther [Internet]. 2019;105(5):1095–105.
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- Verbelen M, Weale ME, Lewis CM. Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? Pharmacogenomics J [Internet]. 2017;17(5):395–402.
- Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, et al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Curr Drug Metab [Internet]. 2014;15(2):209–17.
- Dickson M, Gagnon JP. Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov [Internet]. 2004;3(5):417–29.
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Pharmacogenomics studies how genetics
affects how drugs affect the human body. The terms
genomics and pharmacology are the sources of the field's
name, which represents the intersection of genetics and
medicine. The discovery of the laws of heredity in 1866
marked the beginning of the area of pharmacogenetics
(PGx). The FDA has established PGx testing
recommendations, so whenever these 250+ drugs are
being reviewed, testing should be considered. Physicians
in the fields of pain management, mental health, and
cardiovascular health are among those who provide PGx
recommendations. Antidepressant medications offer
several therapeutic options that are similar, which makes
them a prime candidate for the use of PGx. It makes sense
that pharmaceutical companies are hesitant to use
pharmacogenomics in clinical investigations given its
relative youth. Clinical trials and pharmacogenomic
testing together have many advantages. Finding
populations with risk factors unrelated to the medication
itself may also be facilitated by pharmacogenetics. Oral
anticoagulants and chemotherapy treatment regimens are
now recommended based on a patient's pharmacogenetic
condition. When it comes to patient dosing,
pharmacogenetic techniques are gradually replacing the
traditional method of depending solely on trial and error.
The present therapeutic application of pharmacogenetics
can also be applied to drug research and development.
Keywords :
Pharmacogenetics, Single Nucleotide Polymorphisms, Adverse Drug Events, Pharmaceutical.