Authors : Atangs Ishaku; Rifkatu Aaron Solomon; Aniefiok Moses

Volume/Issue : Volume 11 - 2026, Issue 5 - May

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DOI : https://doi.org/10.38124/ijisrt/26May628

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Abstract : There has been increasing prevalence of sickle cell disease (SCD) with attendant consequences in Nigeria with low uptake of genetic counseling and testing as an effective preventive measure by young adults. This study aimed at examining the perceived need for genetic counseling and testing for SCD in Tudun Wada, Jos North Local Government Area of Plateau State towards prevention of SCD in the society. A descriptive cross sectional study design was adopted and the instrument for data collection was a researcher created Young Adults Genetic Counseling and Testing Questionnaire (YAGCAT-Q). Purposive and snowball sampling technique was used to sample 238 young adults between the ages of 18 to 45 years who were of marriageable age. The data obtained were analyzed using combination of Statistical Package for Social Sciences (SPSS) version 2.5, a descriptive statistic summarized into mean value and presented in tables. The results revealed poor attitude and poor uptake of genetic sickle cell screening by young adults as only 68 (28.57%) have ever participated in the procedure, despite 191 (80.25%) claiming they would avail themselves of the services. Attainment of higher educational level of 98 (41.2%) and prior knowledge of genotype status – 68 (28.57%) were found to be positive influencer as respondents with knowledge on genetic counselling and testing have cumulative mean of 2.896 indicating higher understanding of genetic screening and counseling. Knowledge on impact of genetic counselling and testing on young adults with cumulative mean of 2.9 while the criterion mean maintained at 2.5 were observed. The implication of this is the urgency for aggressive education of young adults for the need for voluntary genetic counselling and testing in order to reduce the prevalence of SCD in our society.

Keywords : Sickle Cell Disease, Genetic Counselling, Genotype Testing, Attitude, Perception.

References :

1. Adesina, O. A., Ogamba, C. F., & Osibogun, A. (2022). Premarital genotype screening for sickle cell disease: knowledge gaps, perception and determinants of uptake among final year undergraduates of a tertiary institution in South-west Nigeria. Nigerian Medical Journal, 63(1), 50–58. https://doi.org/10.60787/nmj.v63i1.94
2. Akoki, A. A.,  Lawal, D. S.,  Oyedokun, J. S., Babawale, A. A., & Agboola, O. A. (2025). A mixed-method study on awareness, haemoglobin phenotype result accuracy and sickle cell knowledge among parents of children with sickle cell disease in Ibadan, Nigeria
3. Adigwe OP. (2022) Knowledge and awareness of sickle cell disease: a cross sectional study amongst unmarried adults in Nigeria's capital city. J Community Genet. 2022
4. Dec;13(6):579-585. doi: 10.1007/s12687-022-00607-x. Epub 2022 Sep 28. PMID: 36171517; PMCID: PMC9681963.
5. Adesola A. Akoki D, Lawal D. Oyedokun A, Babawale A and  Agboola O. (2-24) Sickle cell Diseases in Nigeria: Why we Must Focus On Advocacy. The Center Forcypoli  www.centerforpolicyimpact.org/2024/09/17/sickle-cell impact in Global Health diseases in Nigeria- why –we-focus-on advocacy
6. Adesina OA, Ogamba CF, Osibog (2022). A Premarital Genotype Screening for Sickle Cell Disease: Knowledge Gaps, Perception and Determinants of Uptake among Final Year
7. Undergraduates of a Tertiary Institution in South-West Nigeria. Niger Med J. 2022 Sep 10;63(1):50-58. doi: 10.60787/NMJ-63-1-94. PMID: 38798965; PMCID: PMC11117037.
8. Adewoyin, A.S. (2015). Management of Sickle Cell Disease: A Review for Physician Education in Nigeria (Sub‐Saharan Africa). Anemia, Volume 2015, Article ID 791498, 21 pages. doi.org
9. Akinyanju, O.O. (2018) Prevalence of Sickle Cell Disease among Children Attending Plateau Specialist Hospital, Jos, Nigeria, 2018 (citing studies up to 2017).
10. Anike CJ and C Okocha E A (2016) . Sickle cell diseases genetic counselling, and testing. REVIEW. Arch Med Health Sci; 4:50-7. Doi: www. 10.4103/2321-4884.183342
11. Anie, K. A., Egunjobi, F. E., & Akinyanju, O. O. (2010). Psychosocial impact of sickle cell disorder: Perspectives from a Nigerian setting. Globalization and Health, 6(1), 1–6.
12. Bademosi, O., Ajike, O., & Olaoye, T. (2016). Knowledge, Attitude and Acceptability of Premarital Genetic Services for Sickle Cell Disease among Undergraduates of a Nigerian Private Tertiary Institution. Texila International Journal of Public Health, 4(3), 12-21.
13. Bulgin D, Tanabe P, Jenerette C. Stigma of Sickle Cell Disease: A Systematic Review. Issues Ment Health Nurs. 2018 Aug;39(8):675-686. doi: 10.1080/01612840.2018.1443530. Epub 2018 Apr 13. PMID: 29652215; PMCID: PMC6186193.
14. CDC (2024). About Sickle Cell www.cdc.gov/sickle-cell/about/index.html
15. Dilli PP, Obeagu E, Tamale A, Ajugwo A, Pius T, Makeri D. Update on the practice of premarital screening for sickle cell traits in Africa: a systematic review and meta-analysis. BMC Public Health. 2024 May 31;24(1):1467. doi: 10.1186/s12889-024-19001-y. PMID: 38822327; PMCID: PMC11143629.
16. Fagbamigbe, A. F., Adebowale, A. S., & Morhason-Bello, I. O. (2015). Survival analysis of time to uptake of modern contraceptives among sexually active women of reproductive age in Nigeria.
17. Kanma-Okafor OJ, Abolarinwa AO, Ojo OY, Ekanem EE. (2022). Sickle cell disease prevention: How prepared are the senior secondary school students in Surulere Local Government Area, Lagos, Nigeria? Afr J Prm Health Care Fam Med.;14(1), a3260. https://doi.org/10.4102/ phcfm.v14i1.3260.
18. Kingsley A., Enang O., Legogie A., Cletus O. and Oshatuyi O. (2019). Prevalence of SCD and other Haemoglobin Variants in Calabar, Cross River State, Nigeria, Annual Research & Review in Biology. DOI:10.9734/ARRB/2019/v33i530132.
19. Nnachi, O. C., et al. (2022). Knowledge of Premarital Genotype Screening Among Women Receiving Care at a Tertiary Centre in Ebonyi State, Nigeria. Haematology International Journal, 6(1), 00207. CDC (2024).
20. Nwabuko O. C., Onwuchekwa U., Iheji O. (2022). An overview of sickle cell disease from the socio-demographic triangle - single-institution. DOI:10.11604/pamj.2022.41.161.27117. www.panafrican-med-journal.com//content/article/41/161/full
21. Oluwole EO, Okoye CD, Ogunyemi AO, Olowoselu OF, Oyedeji OA. (2022) Knowledge, attitude and premarital screening practices for sickle cell disease among young unmarried adults in an urban community in Lagos, Nigeria. Pan Afr Med J. 2022 May 6;42:8. doi: 10.11604/pamj.2022.42.8.27705. PMID: 35685388; PMCID: PMC9142780.
22. Saratu O. Ajike, Olufisayo. A Bademosi, Titilayo Olaoye (2025) Knowledge, Attitude and Acceptability of Premarital Genetic Services for Sickle Cell Disease among Undergraduates of a Nigerian Private Tertiary Institution DOI: 10.21522/TIJPH.2013.04.03.Art002
23. Sarpong, M.L., Tetteh, R.J., Amponsah, F.A. et al. Young adults’ knowledge, attitudes, and practices regarding premarital screening for genetic blood disorders and associated sociodemographic determinants in the Ahafo Region of Ghana: a cross-sectional study. Arch Public Health 83, 128 (2025). https://doi.org/10.1186/s13690-025-01611-6
24. Yussif AK, Osei-Tutu A, Osae-Larbi JA. Perceptions of sickle cell disease and genetic counseling among single young adults in Tamale, Ghana. J Community Genet. 2025 Dec;16(6):775-786. doi: 10.1007/s12687-025-00825-z. Epub 2025 Aug 12. PMID: 40794126; PMCID: PMC12569235.
25. Weatherall, D. J. (2010). The inherited disorders of hemoglobin: An increasingly neglected global health burden. Indian Journal of Medical Research, 132(4), 365–369.
26. WHO. (2010). Sickle-cell disease: A strategy for the WHO African Region. World Health Organization.
27. WHO. (2025). www.who.int/news-room/fact-sheets/sickle-cell-disease