Authors :
Adwoa Amankwa Owusu; Bolajoko Aina; Grace Owusu Aboagye; Eugene Kyere Oppong
Volume/Issue :
Volume 11 - 2026, Issue 7 - July
Google Scholar :
https://tinyurl.com/5fayv9p8
Scribd :
https://tinyurl.com/yuk7d2m4
DOI :
https://doi.org/10.38124/ijisrt/26jul438
Note : A published paper may take 4-5
working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and
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Abstract :
Background:
Medication non-adherence in schizophrenia remains a critical determinant of relapse, poor functional outcomes, and
increased healthcare utilization. Identifying modifiable predictors of adherence is essential for informing targeted and
scalable interventions, particularly in resource-constrained settings.
Methods:
A hospital-based cross-sectional study was conducted among 187 patients with schizophrenia at Komfo Anokye
Teaching Hospital, Ghana. Data were collected using structured questionnaires, including the Medication Adherence
Rating Scale (MARS). Associations between adherence and predictor variables were examined using Pearson’s correlation
and multivariable linear regression. Statistical significance was set at p < 0.05.
Keywords :
Schizophrenia; Medication Adherence; Patient–Provider Communication; Psychoeducation; MARS; Low- And Middle-Income Countries.
References :
- Acosta, F., Bosch, E., Sarmiento, G., Juanes, N., Caballero-Hidalgo, A., & Mayans, T. (2022). Evaluation of noncompliance in schizophrenia patients using electronic monitoring (MEMS) and its relationship to clinical variables. Schizophrenia Research, 107, 213–217. https://doi.org/10.1016/S0920-9964(08)70219-6
- Ascher-Svanum, H., Faries, D., Zhu, B., Ernst, F., Swartz, M., & Swanson, J. (2024). Medication adherence and long-term outcomes in schizophrenia. Journal of Clinical Psychiatry, 67, 453–460. https://doi.org/10.4088/JCP.v67n0312
- Byerly, M. J., Nakonezny, P. A., & Lescouflair, E. (2023). Antipsychotic medication adherence in schizophrenia. Psychiatric Clinics of North America, 30, 437–452. https://doi.org/10.1016/j.psc.2023.03.001
- Delgadillo, J., et al. (2020). The therapeutic alliance and treatment outcomes. Psychotherapy Research, 30(1), 1–12. https://doi.org/10.1080/10503307.2019.1652212
- Elwyn, G., et al. (2017). Shared decision making in healthcare. BMJ, 359, j4891. https://doi.org/10.1136/bmj.j4891
- Horne, R., & Weinman, J. (2015). The necessity–concerns framework. British Journal of Health Psychology, 20(4), 1–15. https://doi.org/10.1111/bjhp.12100
- Kane, J. M., et al. (2019). Treatment adherence and antipsychotic medications. Journal of Clinical Psychiatry, 80(2), 1–8. https://doi.org/10.4088/JCP.18r12469
- Kane, J. M., et al. (2023). Psychoeducation and relapse prevention in schizophrenia. Schizophrenia Bulletin, 49(2), 1–10. https://doi.org/10.1093/schbul/sbad045
- Law, M. R., Soumerai, S. B., Ross-Degnan, D., Adams, A., & others. (2023). Medication nonadherence and hospitalization risk. Journal of Clinical Psychiatry, 69, 47–53. https://doi.org/10.4088/JCP.21m14234
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- Lincoln, T. M., Wilhelm, K., & Nestoriuc, Y. (2019). Psychoeducation for schizophrenia. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13002
- Patel, V., et al. (2018). The Lancet Commission on global mental health. The Lancet, 392(10157), 1553–1598. https://doi.org/10.1016/S0140-6736(18)31612-X
- Sajatovic, M., et al. (2020). Family support and medication adherence. Psychiatric Services, 71(6), 1–8. https://doi.org/10.1176/appi.ps.201900128
- Stacey, D., et al. (2017). Decision aids for people facing health decisions. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD001431.pub5
- Vrijens, B., et al. (2017). A new taxonomy for adherence. British Journal of Clinical Pharmacology, 82(1), 1–16. https://doi.org/10.1111/bcp.12979
- Wang, L., Chen, Y., Hu, C., & Qin, H. (2021). Family dynamics and stigma in schizophrenia. Frontiers in Psychiatry, 12, 645075. https://doi.org/10.3389/fpsyt.2021.645075
- World Health Organization. (2016). Medication adherence in chronic diseases. https://doi.org/10.1097/01.npr.0000207003.21590.4e
- World Health Organization. (2021). Evidence-based treatments for schizophrenia: Information for families and other supporters. Arlington, VA: American Psychiatric Association Publishing.
Available at: https://www.psychiatry.org/patients-families/schizophrenia
- Zhou, X., et al. (2023). Digital interventions for improving adherence. JMIR Mental Health. https://doi.org/10.2196/42856
- Zolnierek, K. B., & DiMatteo, M. R. (2018). Physician communication and patient adherence. Medical Care, 47(8), 826–834. https://doi.org/10.1097/MLR.0b013e31819a5acc
Background:
Medication non-adherence in schizophrenia remains a critical determinant of relapse, poor functional outcomes, and
increased healthcare utilization. Identifying modifiable predictors of adherence is essential for informing targeted and
scalable interventions, particularly in resource-constrained settings.
Methods:
A hospital-based cross-sectional study was conducted among 187 patients with schizophrenia at Komfo Anokye
Teaching Hospital, Ghana. Data were collected using structured questionnaires, including the Medication Adherence
Rating Scale (MARS). Associations between adherence and predictor variables were examined using Pearson’s correlation
and multivariable linear regression. Statistical significance was set at p < 0.05.
Keywords :
Schizophrenia; Medication Adherence; Patient–Provider Communication; Psychoeducation; MARS; Low- And Middle-Income Countries.