Although nasopharyngeal carcinoma (NPC) has a high tendency for early distant spread, orbital and ocular adnexa metastases are rare. This paper reports a 10-year-old female child previously diagnosed with a locally advanced NPC, she was treated with neoadjuvant chemotherapy based on bleomycin, epirubicin, and cisplatin (BEC) protocol with a low radiological response, Afterward, the management was supplemented by concomitant chemoradiotherapy. The patient subsequently presented bilateral painful palpable masses in the medial canthal area with mild proptosis, redness, and decreased visual acuity. The cervical facial scan showed bilateral tissue formations of the internal canthus, related to secondary locations. The cerebral scan showed a tissue formation of the frontal bone, enhanced after contrast without periosteal reaction, related to a secondary location. Subsequently, the patient received two cycles of palliative chemotherapy. The evolution was marked by the progression of orbital metastases. The patient died two months after the diagnosis of orbital metastases. In this case report, we illustrate a new case of a pediatric nasopharyngeal carcinoma with orbital metastasis and report the clinicopathological features and therapeutics interventions, as well as the outcomes of this aggressive disease.

Keywords : Orbital Metastases, Nasopharyngeal Carcinoma, Radiotherapy, Chemotherapy, Imaging