Phytosome process has been applied to many
popular herbal extract including Gingko biloba, grape
see, hawthorn, milk thistle, green tea and ginseng. The
flavonoids and terpenoid components of these herbal
extracts lend themselves quite well for the direct binding
to Phosphatidylcholine. Phytosomes is produced by
binding individual components of herbal extract to
phosphatidylcholine, resulting in a dosage form that is
better absorbed and thus, produces better result than the
conventional herbal extract.
According to this research, design of experiments
(DoE) is an efficient, elegant, and cost-effective statistical
technique that delivers more knowledge with the least
number of runs. Soya lecithin (X1), reaction temperature
(X2), and reaction time (X3) were all significant
parameters impacting phytosome response
characteristics, according to standardised response
surface plots, with p 0.05. The precision of the data was
demonstrated by significant (p 0.05) model F-values and
non-significant (p > 0.05) “lack of fit F-values” for
response variables. R2 Adj (adjusted R-squared) and R2
Anticipated (expected R-squared) (R2 Pred) values
indicated that the regression coefficients were fairly
consistent. A lower PRESS value in regression models
indicated a better match. The model discrimination was
adequate, according to a high precision (AP) value. The
normality of the response data was demonstrated using
standard probability plots. Externally studentized
residuals vs. expected values of the response parameters
revealed the absence of constant error. The absence of
lurking variables was investigated using a residual vs. run
plot.
Keywords :
Nisomes, Taraxacum officinale, Box-Behnken Design.