One Pot and Three Component Synthesis of 4-aryl-3- Methylisoxazole-5(4H)-One Derivative in the Presence of Sodium Hypophosphite


Authors : Amit P.Tayade, Ramkrushna P. Pawar, Rajiv V. Khobare, Chandakant B.Mane, Nitin P. Tayde

Volume/Issue : Volume 4 - 2019, Issue 11 - November

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/2Ycns0w

Abstract : sodium hypophosphite is also an effective catalyst use for one pot three component reaction contain ethyl acetoacetate react with hydroxylamine hydrochloride and various aromatic aldehyde, gives iso-oxazole. This reaction carried out in water at 800 C temperature . The product obtained with high yield in convenient time up to 1-2 hours.

Keywords : MCR, Aldehyde , Ethyl Acetoacetate , Hydroxylamine Hydrochloride , Sodium Hypophosphite, Green.

sodium hypophosphite is also an effective catalyst use for one pot three component reaction contain ethyl acetoacetate react with hydroxylamine hydrochloride and various aromatic aldehyde, gives iso-oxazole. This reaction carried out in water at 800 C temperature . The product obtained with high yield in convenient time up to 1-2 hours.

Keywords : MCR, Aldehyde , Ethyl Acetoacetate , Hydroxylamine Hydrochloride , Sodium Hypophosphite, Green.

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