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Numerical Computation and Epidemiological Risk Analysis of Sepsis Mortality among Adults with ICD-Coded Sepsis in MIMIC-IV


Authors : Innocent Obinna Okpara; Roseline Toyin Abah; Mary O. Durojaye

Volume/Issue : Volume 11 - 2026, Issue 8 - August


Google Scholar : https://tinyurl.com/bdu9fpx4

DOI : https://doi.org/10.38124/ijisrt/26aug1493

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background: Transparent cohort characterization is a prerequisite for reliable sepsis prediction research, yet case definitions, admission units, outcome windows, and leakage controls vary considerably across studies.  Methods: We conducted a retrospective descriptive analysis of adult hospital admissions in MIMIC-IV version 3.1. Admissions were identified using an explicit ICD-coded sepsis phenotype. The primary modelling population was defined as the chronologically first eligible coded-sepsis admission per patient; all eligible admissions were retained for descriptive analyses. Outcomes included in-hospital, 30-day, and 90-day mortality. We summarized demographic characteristics, ICU involvement, coded severity, first ICU care unit, and the availability of ten candidate physiological variables. Unadjusted mortality differences and risk ratios were calculated from the reported stratum counts.

Keywords : Sepsis; Mortality; MIMIC-IV; Retrospective Cohort; Intensive Care; Missing Data; Electronic Health Records.

References :

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Background: Transparent cohort characterization is a prerequisite for reliable sepsis prediction research, yet case definitions, admission units, outcome windows, and leakage controls vary considerably across studies.  Methods: We conducted a retrospective descriptive analysis of adult hospital admissions in MIMIC-IV version 3.1. Admissions were identified using an explicit ICD-coded sepsis phenotype. The primary modelling population was defined as the chronologically first eligible coded-sepsis admission per patient; all eligible admissions were retained for descriptive analyses. Outcomes included in-hospital, 30-day, and 90-day mortality. We summarized demographic characteristics, ICU involvement, coded severity, first ICU care unit, and the availability of ten candidate physiological variables. Unadjusted mortality differences and risk ratios were calculated from the reported stratum counts.

Keywords : Sepsis; Mortality; MIMIC-IV; Retrospective Cohort; Intensive Care; Missing Data; Electronic Health Records.

Paper Submission Last Date
30 - September - 2026

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