Authors : Kothwala Dr. Deveshkumar; Rana Niravkumar Maheshbhai; Gurang Deepak Dhanbahdur

Volume/Issue : Volume 9 - 2024, Issue 11 - November

Google Scholar : https://tinyurl.com/4mmvrdrt

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DOI : https://doi.org/10.38124/ijisrt/IJISRT24NOV886

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Abstract : Pulmonary embolism (PE) is a serious complication of deep vein thrombosis (DVT) and peripheral artery disease, often leading to fatal outcomes. The first line of treatment for DVT and PAD is anticoagulation: preventing the thrombus, occlusion of blood vessels, and propagation of PE especially in the case of DVT where limb or life-threatening complications are at risk. Clots retrieved from vessels include mechanical and manual interventions such as catheter-directed thrombolysis and thrombectomy. Yet the risks involved with thrombotic and embolic vascular occlusions are high because they cause occlusion of blood flow in crucial vessels; this may lead to tissue damage, organ failure, and death. Most of the existing thrombectomy devices do not remove the organized thrombus completely while prevention of clot fragmentation is also lacking. The study presents a new, self-expanding laser-cut clot retrieval device specifically designed to remove both hard and soft thrombi with no trauma at all to the vessel wall. This is one of the promising advancements in thrombectomy that overcomes the disadvantages of other existing technologies and offers a stronger approach for the removal of occlusions in the vascular system associated with DVT, PAD, and PE. The simulation test in vitro and a trackability test have been conducted with the developed device together with its delivery system for validation. These tests were envisaged to demonstrate how the device can operate, for example, navigate through the vasculature, and retrieve thrombi safely and accurately.

Keywords : Pulmonary Embolization, Ischemic Stroke, Deep Vein Thrombolysis (DVT), Peripheral Artery Disease (PAD), Catheter-Directed Thrombolysis (CDT), Mechanical Thrombectomy Device (MTD), Post-Thrombotic Syndrome (PTS), Biocompatibility.

References :

1. Monsky WL, Finitsis S, De Cicco D, Brock JM, Kucharczyk J, Latchaw RE. A novel mechanical thrombectomy device for retrieval of intravascular thrombus. Cardiovasc Intervent Radiol. 2011 Apr;34(2):383-90. doi: 10.1007/s00270-010-0024-7. Epub 2010 Nov 12. PMID: 21069329; PMCID: PMC3058340.
2. Ramaswamy R, Guttikonda A, Kaplan MD. Mechanical extraction of chronic venous thrombus using a novel device: a report of two cases. J Vasc Surg Cases Innov Tech. 2022 Sep 29;8(4):752-755. doi: 10.1016/j.jvscit.2022.09.011. PMID: 36438666; PMCID: PMC9691468.
3. 2021Applicability assessment of a stent-retriever thrombectomy finite-element modelInterface Focus.1120190123 http://doi.org/10.1098/rsfs.2019.0123
4. Luraghi G, Rodriguez Matas JF, Dubini G, Berti F, Bridio S, Duffy S, Dwivedi A, McCarthy R, Fereidoonnezhad B, McGarry P, Majoie CBLM, Migliavacca F; INSIST investigators. Applicability assessment of a stent-retriever thrombectomy finite-element model. Interface Focus. 2021 Feb 6;11(1):20190123. doi: 10.1098/rsfs.2019.0123. Epub 2020 Dec 11. PMID: 33343873; PMCID: PMC7739910.
5. Hung, Ming-Ya, Chun-Kai Yang, Jiong-Hong Chen, Li-Han Lin, and Hao-Ming Hsiao. 2021. "Novel Blood Clot Retriever for Ischemic Stroke" Micromachines 12, no. 8: 928. https://doi.org/10.3390/mi12080928
6. Pierre K, Perez-Vega C, Fusco A, Olowofela B, Hatem R, Elyazeed M, et al. Updates in mechanical thrombectomy. Explor Neurosci. 2022;1:83–99. https://doi.org/10.37349/en.2022.00007
7. Monsky, W.L., Finitsis, S., De Cicco, D. et al. A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular Thrombus. Cardiovasc Intervent Radiol 34, 383–390 (2011). https://doi.org/10.1007/s00270-010-0024-7
8. A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular Thrombus,3 John M. Brock,1 John Kucharczyk,4 and Richard E. Latchaw.
9. Successful removal of aWayne L. Monsky, 1 Stephanos Finitsis,2 Dino De Ciccon acute deep vein thrombosis by the INARI ClotTriever system Erina Quinn, BA,a,⁎ Mary Arndt, BS, MSa,a James Capanegro, BS, MMS,a and Douglass Sherard, MDb
10. Catheter-Directed Interventions for the Treatment of Lower Extremity Deep Vein Thrombosis by Kajol J. Shah 1,*ORCID andTrisha L. Roy 2
11. Pulmonary Embolism (PE)   Author: Daniel R Ouellette, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP
12. Thrombosis Damilola Ashorobi; Muhammad Atif Ameer; Roberto Fernandez.
13. Thrombectomy Shibin Mathews; Orlando De Jesus.
14. A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular ThrombusWayne L. Monsky, Stephanos Finitsis, Dino De Cicco, John M. Brock, John Kucharczyk & Richard E. Latchaw