Authors : Rahul R. K.; Aswathy M.

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/msj2c4kw

Scribd : https://tinyurl.com/5cyfbswt

DOI : https://doi.org/10.38124/ijisrt/26May1017

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Abstract : Neuroplasticity is a key mechanism underlying recovery in neurological disorders, allowing the brain to reorganize and adapt after injury or degeneration. Recent research suggests that acupuncture may influence neuroplastic processes through modulation of cortical activity, synaptic remodelling, neurogenesis, and neurotrophic signalling. This narrative review examines contemporary evidence on the neuroplastic effects of acupuncture, with particular focus on stroke and Parkinson’s disease. Recent neuroimaging and mechanistic studies indicate that acupuncture may affect sensorimotor networks, dopaminergic pathways, and inflammatory regulation associated with functional recovery. In stroke, acupuncture has been linked to improved motor-network activation and neurorepair-related signalling, while in Parkinson’s disease it may support dopaminergic preservation and circuit-level plasticity. Current evidence supports the view that acupuncture may function as a neuromodulatory adjunct in neurorehabilitation, particularly when combined with conventional rehabilitation strategies. However, further standardized and large-scale studies are required to strengthen clinical translation.

Keywords : Acupuncture; Neuroplasticity; Stroke; Parkinson’s Disease; Neuromodulation; Neurorehabilitation.

References :

1. Qin S, Zhang Z, Zhao Y, Liu J, Qiu J, Gong Y, et al. The impact of acupuncture on neuroplasticity after ischemic stroke: a literature review and perspectives. Frontiers in Cellular Neuroscience. 2022;16: 817732. https://doi.org/10.3389/FNCEL.2022.817732.
2. Mu JD, Ma LX, Zhang Z, Qian X, Zhang QY, Ma LH, et al. The factors affecting neurogenesis after stroke and the role of acupuncture. Frontiers in Neurology. 2023;14: 1082625. https://doi.org/10.3389/FNEUR.2023.1082625/FULL.
3. Zhou Y, Dai A, Feng S, Zhu T, Liu M, Shi J, et al. Immediate neural effects of acupuncture manipulation time for stroke with motor dysfunction: a fMRI pilot study. Frontiers in Neuroscience. 2023;17: 1297149. https://doi.org/10.3389/FNINS.2023.1297149/TEXT.
4. Zhang J, Huang W, Chen Z, Jiang H, Su M, Wang C. Effect of auricular acupuncture on neuroplasticity of stroke patients with motor dysfunction: A fNIRS study. Neuroscience Letters. 2023;812: 137398. https://doi.org/10.1016/J.NEULET.2023.137398.
5. Oh JY, Lee H, Jang SY, Kim H, Park G, Serikov A, et al. Central Role of Hypothalamic Circuits for Acupuncture’s Anti-Parkinsonian Effects. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024;11(43). https://doi.org/10.1002/ADVS.202403245.
6. Zhou Y, Dai A, Feng S, Zhu T, Liu M, Shi J, et al. Immediate neural effects of acupuncture manipulation time for stroke with motor dysfunction: a fMRI pilot study. Frontiers in neuroscience. 2024;17. https://doi.org/10.3389/FNINS.2023.1297149.
7. Oh JY, Lee H, Jang SY, Kim H, Park G, Serikov A, et al. Central Role of Hypothalamic Circuits for Acupuncture’s Anti-Parkinsonian Effects. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024;11(43). https://doi.org/10.1002/ADVS.202403245.
8. Xue H, He HX, Wu D, Fan WH, Li YX. An overview of systematic reviews of acupuncture for Parkinson’s disease. Frontiers in Neuroscience. 2024;18: 1415008. https://doi.org/10.3389/FNINS.2024.1415008/TEXT.
9. Zhuo B, Deng S, Li B, Zhu W, Zhang M, Qin C, et al. Possible Effects of Acupuncture in Poststroke Aphasia. Behavioural Neurology. 2023;2023(1): 9445381. https://doi.org/10.1155/2023/9445381.
10. Shen D, Yang B, Li J, Gao S. Effect of acupuncture treatment for upper limb on cortical activation and functional connectivity: A fNIRS study. Biomedical Signal Processing and Control. 2025;99: 106915. https://doi.org/10.1016/J.BSPC.2024.106915.