Babies under one year old are vulnerable to COVID-19. However, the vulnerabilities of neonates born to infected mothers are lack studied. Newborns from mothers with suspected or confirmed cases of COVID-19 must be clinically examined for SARS-CoV2. Laboratory examination is recommended for disease diagnosis and progression. This research assessed the lymphocyte, neutrophil, thrombocyte, c-reactive protein (CRP), and procalcitonin (PCT) in neonates born from COVID-19 positive and negative mothers. A retrospective cross-sectional study involving 113 neonates and 110 neonates from COVID-19 positive and negative mothers was carried out in Haji Adam Malik hospital Medan, Indonesia. All data was collected from the medical record. Mann-Whitney statistical test was carried out to assess the difference in lymphocyte,

Keywords : COVID-19, diagnosis, neonates, blood work