Authors : Priyam Jain; Dr. Aniruddha Pare; Vikas Kumar

Volume/Issue : Volume 11 - 2026, Issue 6 - June

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Google Scholar : https://tinyurl.com/ybr6wx66

Scribd : https://tinyurl.com/4e29m8jj

DOI : https://doi.org/10.38124/ijisrt/26jun1025

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Abstract : Background Aphthous stomatitis is a recurrent inflammatory disorder of the oral mucosa associated with painful ulcers that affect normal activities such as eating and speaking. Conventional oral formulations show limited effectiveness because they are rapidly removed from the oral cavity. Nanostructured lipid carrier (NLC)-based mucoadhesive gels have emerged as a promising strategy for improving drug retention, stability, and localized therapeutic action.  Aim The aim of the present study was to formulate and optimize a Lycopene and Coenzyme Q10-loaded NLC mucoadhesive gel for the treatment of aphthous stomatitis and to evaluate its physicochemical and therapeutic properties.

Keywords : Aphthous Stomatitis; Nanostructured Lipid Carriers; Mucoadhesive Gel; Lycopene; Coenzyme Q10; Box–Behnken Design; Buccal Delivery; In Vivo Study.

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