Nanosizing – Oral Formulation Development


Authors : Shubham Yadav; Dr. Swarup J. Chatterjee

Volume/Issue : Volume 9 - 2024, Issue 12 - December

Google Scholar : https://tinyurl.com/3xdhy45z

Scribd : https://tinyurl.com/32n74283

DOI : https://doi.org/10.5281/zenodo.14525495

Abstract : One of the main issues in drug development is poor water solubility, which prevents most medications from achieving sufficient oral bioavailability. The decrease of an API's size to the sub-micron level is known as nanosizing, and the final particle size typically falls between 100 and 200 nm. The API's rate of dissolution is significantly increased by the reduction in particle size, which ultimately results in a large increase in bioavailability. The principles guiding nanosizing, the creation and characterisation of nanoformulations, and the current state of use of such formulations are all intended to be highlighted in this paper.

Keywords : Particle Size, Nanosizing Technique, Solubility, Absorption and Bioavailability.

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One of the main issues in drug development is poor water solubility, which prevents most medications from achieving sufficient oral bioavailability. The decrease of an API's size to the sub-micron level is known as nanosizing, and the final particle size typically falls between 100 and 200 nm. The API's rate of dissolution is significantly increased by the reduction in particle size, which ultimately results in a large increase in bioavailability. The principles guiding nanosizing, the creation and characterisation of nanoformulations, and the current state of use of such formulations are all intended to be highlighted in this paper.

Keywords : Particle Size, Nanosizing Technique, Solubility, Absorption and Bioavailability.

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