Authors : Dr. Rashmi Sharma; Dr. Shushmita Mishra

Volume/Issue : Volume 11 - 2026, Issue 5 - May

Google Scholar : https://tinyurl.com/bddbsz3z

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DOI : https://doi.org/10.38124/ijisrt/26May393

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Abstract : Phytochemicals separated from medicinal herbs have a broad range of pharmacological activities like antiinflammatory, antioxidant, anticancer, and antimicrobial activities. However, their application in clinical settings is greatly limited due to poor bioavailability that results from factors such as low solubility in water, poor permeability, instability, and significant first-pass metabolism. Based on nanotechnology, drug delivery systems emerged as a revolutionary solution to address these challenges. This review provides a wide and critical overview on the use of nano-enabled delivery systems to phytochemicals, such as polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions and novel hybrid systems. It discusses the mechanisms of bioavailability enhancement, recent advances (2019–2026), therapeutic applications, and translation challenges. The review also covers regulatory issues and future opportunities for the clinical use of.

Keywords : Phytoconstituents, Nanotechnology, Bioavailability, Herbal Drugs, Nanocarriers, Drug Delivery.

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