Authors :
Ria Patela; Jaydev Patela; Manthan Prajapatia; Kenil Choksia; PriyanshuThakera; DhruvilGajeraa; Madhav Oza
Volume/Issue :
Volume 8 - 2023, Issue 1 - January
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3iPpwKX
DOI :
https://doi.org/10.5281/zenodo.7554225
Abstract :
Herpes viruses are found in the order
primates which are classified into three subfamilies:
alpha, beta, and gamma. Herpes Simiae (B virus) is
found in rhesus long-tailed monkeys employed in
scientific research. The most prevalent mode of
transmission of the Monkey B virus is by contact with
monkey saliva, tissues, or tissue fluids. A breach of
primary skin or mucosal defences leads to human
infection, followed by contamination of the site with
virus from this animal. The infection affects 75% of
macaques and is transferred to people having horizontal
contact with macaques, showing 70% mortality. After
transmission, minor flu symptoms appear, which
subsequently impact various body areas with varying
signs and symptoms. This infection is difficult to cure
once it has progressed and entered the human host cycle
since there are no or few therapeutic options available,
one of which is the use of acyclovir. Without treatment, a
4:9 mortality rate has been documented in several
studies. The current study updates prior guidelines for
the prevention, assessment, and treatment of human B
virus infection and addresses the significance of newer
antiviral medicines in post-exposure prophylaxis, as well
as the necessity to prioritize preventative measures when
conducting scientific research
Keywords :
Monkey B virus; MBV; herpesvirus simiae; encephalomyelitis; biomedical research; antiviral therapy.
Herpes viruses are found in the order
primates which are classified into three subfamilies:
alpha, beta, and gamma. Herpes Simiae (B virus) is
found in rhesus long-tailed monkeys employed in
scientific research. The most prevalent mode of
transmission of the Monkey B virus is by contact with
monkey saliva, tissues, or tissue fluids. A breach of
primary skin or mucosal defences leads to human
infection, followed by contamination of the site with
virus from this animal. The infection affects 75% of
macaques and is transferred to people having horizontal
contact with macaques, showing 70% mortality. After
transmission, minor flu symptoms appear, which
subsequently impact various body areas with varying
signs and symptoms. This infection is difficult to cure
once it has progressed and entered the human host cycle
since there are no or few therapeutic options available,
one of which is the use of acyclovir. Without treatment, a
4:9 mortality rate has been documented in several
studies. The current study updates prior guidelines for
the prevention, assessment, and treatment of human B
virus infection and addresses the significance of newer
antiviral medicines in post-exposure prophylaxis, as well
as the necessity to prioritize preventative measures when
conducting scientific research
Keywords :
Monkey B virus; MBV; herpesvirus simiae; encephalomyelitis; biomedical research; antiviral therapy.
