Authors : Hanumant S. Suryawanshi; Dr. Ashish B. Gulwe

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/yhdrbbr3

Scribd : https://tinyurl.com/573xrpxm

DOI : https://doi.org/10.38124/ijisrt/26apr428

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Abstract : Alzheimer’s disease (AD) is a gradually worsening neurodegenerative condition characterized by cognitive decline and memory damage, primarily associated with reduced cholinergic neurotransmission. Acetylcholinesterase (AChE) is essential for the breakdown of acetylcholine, making it an important target for therapeutic intervention. This study investigates the inhibitory potential of selected fungal bioactive compounds against human acetylcholinesterase (AChE; PDB ID: 4EY7) using molecular docking techniques. A library of fungal metabolites was screened and evaluated in comparison with the standard drug donepezil. Docking analysis was carried out using AutoDock Vina, with binding affinities, molecular interactions, and ADMET properties assessed. Several compounds exhibited strong binding affinities and favorable pharmacokinetic characteristics, indicating their promise as potential lead candidates for anti-Alzheimer’s drug development.

Keywords : Alzheimer’s Disease, Bioactive Compounds, Molecular Docking, Acetylcholinesterase.

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