This article deals with anticancer studies of
phytochemicals identified from Solenostemma Argel leaf
extract using GC-MS analysis and molecular docking
studies. B cell lymphoma-2 (BCL-2) agonists are useful
for regulating apoptosis which is essential for several
cancers. The aim of the present study is to investigate
the BCl-2 agonist property of phytochemicals from the
extract of S. Argel using an Insilco approach. The
docking on human BCL-2 protein was determined by
GOLD 3.0.1 software. It is concluded from the studies
that compound suggested by GCMS at RT 17.1 minute
is 4,5,7-trihydroxy isoflavone showed best result with
highest fitness index
Keywords :
Cancer; Docking studies; BCL-2; Solenostemma argel
