Adenoid cystic carcinoma (ACC) is rare neoplasia of salivary glands, constitutes 7-10% of salivary gland neoplasms. It occurs in both major and minor salivary glands however found in other sites like head and neck, lung, breast, female genital tract, prostate and skin. It is a slow-growing tumour with gradual evolution, quite aggressive locally with perineural spread, tendency towards local recurrence and distant metastasis. This is a case report and review analysis of adenoid cystic carcinoma of salivary gland and other sites. Hereby we report a 53-year-old female, post-operative case of adenoid cystic carcinoma of submandibular gland remained asymptomatic for 6 years after treatment with radiotherapy alone, now developed metastases to lung. Performance status is 2 therefore metastasis was challenged with Adriamycin based chemotherapy. After four cycles of chemotherapy desired response was not achieved hence palliative radiotherapy to lung lesion was planned.

Keywords : Adenoid Cystic Carcinoma, Cribriform Pattern, Submandibular Gland.