Authors : Jaanvi Roy ; Richa Roy

Volume/Issue : Volume 10 - 2025, Issue 5 - May

Google Scholar : https://tinyurl.com/yvkxbwsw

DOI : https://doi.org/10.38124/ijisrt/25may1416

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Macrophages are pivotal immune cells that contribute significantly to the regulation of uterine receptivity and embryo implantation. Their ability to polarize into functionally distinct subtypes—pro-inflammatory (M1) and anti- inflammatory (M2)—allows them to adapt to different phases of the reproductive cycle. During implantation, macrophages aid in tissue remodelling, angiogenesis, and immune tolerance, all crucial for successful embryo development. However, dysfunctions in macrophage polarization have been increasingly associated with implantation failure and infertility, especially in cases involving endometriosis, chronic endometritis, and metabolic disorders. Understanding their roles opens new diagnostic and therapeutic avenues for enhancing fertility outcomes, especially in IVF treatments.

Keywords : Jaanvi Roy; Richa Roy; (2025). Macrophage & Endometrial Receptivity. International Journal of Innovative Science and Research Technology, 10(5), 3815-3818. https://doi.org/10.38124/ijisrt/25may1416

References :

[1] Mor, G., & Abrahams, V. M. (2003). Potential role of macrophages as immunoregulators of pregnancy. Reproductive Biology and Endocrinology, 1(1), 119.

[2] Svensson-Arvelund, J., & Ernerudh, J. (2015). The role of macrophages in promoting and maintaining homeostasis at the fetal–maternal interface. American Journal of Reproductive Immunology, 74(2), 100–109.

[3] Brown, M. B., & Johnson, P. E. (2021). Macrophage dysfunction and infertility. Fertility and Sterility, 116(3), 605–613.

[4] Wu, X., & Jin, L. P. (2019). Immune cells in the endometrium and their roles in embryo implantation. Frontiers in Immunology, 10, 289.

[5] Gonzalez, T. L., & Gaskins, A. J. (2020). Immune profile and implantation outcomes in IVF: macrophage-mediated mechanisms. Human Reproduction Update, 26(2), 153–171.