Lifestyle and the Gut-Brain Axis Insights into Mental Health and Microbiome Interactions


Authors : Shivangi Sharma

Volume/Issue : Volume 9 - 2024, Issue 11 - November

Google Scholar : https://tinyurl.com/vb5krrun

Scribd : https://tinyurl.com/yc48sace

DOI : https://doi.org/10.38124/ijisrt/IJISRT24NOV235

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Abstract : Introduction: The intricate relationship between lifestyle factors and gut health has become a focus of recent research, emphasizing the significant role of the gut-brain axis (GBA) in regulating both physical and emotional well- being. Unhealthy lifestyle choices, including a diet high in ultra-processed foods, irregular sleep patterns, physical inactivity, and substance abuse, have been closely associated with gut dysbiosis, leading to gastrointestinal (GI) symptoms and mood disturbances such as anxiety and depression. The gut microbiota, through the production of neurotransmitters like serotonin and dopamine, as well as short-chain fatty acids (SCFAs), influences mood and mental health via the GBA. Maintaining a healthy lifestyle, characterized by balanced nutrition, regular physical activity, and good sleep quality, is critical in fostering a diverse and stable gut microbiome, which in turn supports emotional stability.  Aim: This review aims to examine the existing literature on the impact of lifestyle factors, such as diet, physical activity, sleep, smoking, alcohol consumption, and stress management, on gut health and emotional well-being. The goal is to highlight the importance of gut microbiota in mental health and the potential therapeutic strategies to enhance gut health for improved emotional outcomes.  Methodology: A comprehensive search of peer-reviewed journal articles was conducted using databases such as PubMed, Google Scholar, and Web of Science. Keywords like "lifestyle," "gut health," "emotional well-being," "dietary habits," "physical activity," "sleep patterns," and "gut-brain axis" were used to identify relevant studies. Inclusion criteria focused on human clinical trials and observational studies published within the last 16 years. Studies involving animal subjects, non-peer- reviewed articles, and outdated research were excluded.  Results: The literature shows that diets high in fiber and low in processed foods support a healthier gut microbiome, while high consumption of ultra-processed foods disrupts gut bacteria, leading to GI symptoms and mood disorders. Regular physical activity was found to enhance gut microbiota diversity, contributing to better emotional well-being. Conversely, poor sleep quality and chronic stress were linked to gut dysbiosis, which exacerbated mood disturbances. Smoking and excessive alcohol consumption further damaged gut health, contributing to mood dysregulation. Probiotic and prebiotic interventions, particularly synbiotics, were found to restore gut balance and improve both GI and mental health outcomes.  Conclusion: This review underscores the pivotal role of lifestyle choices in shaping gut health and emotional well-being. A balanced diet, regular exercise, sufficient sleep, and stress management are essential for maintaining a healthy gut microbiome, which, in turn, supports emotional stability. Therapeutic strategies involving prebiotics, probiotics, and synbiotics offer promising avenues for improving both gut health and mood. Addressing lifestyle factors and promoting gut health can potentially serve as an effective approach for enhancing overall well-being and preventing mood disorders.

Keywords : Gut-Brain Axis, Gut Health, Lifestyle Factors, Emotional Well-Being, Diet, Physical Activity, Probiotics, Prebiotics.

References :

  1. Adjibade, M., Julia, C., Allès, B., Touvier, M., Lemogne, C., Srour, B., Hercberg, S., Galan, P., Assmann, K. E., & Kesse-Guyot, E. (2019). Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Santé cohort. BMC Medicine, 17(1), 78. https://doi.org/10.1186/s12916-019-1312-y
  2. Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016). Bifidobacterium longum 1714 as a translational psychobiotic: Modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry, 6(11), e939–e939. https://doi.org/10.1038/tp.2016.191
  3. Atzeni, A., Martínez, M. Á., Babio, N., Konstanti, P., Tinahones, F. J., Vioque, J., Corella, D., Fitó, M., Vidal, J., Moreno-Indias, I., Pertusa-Martinez, S., Álvarez-Sala, A., Castañer, O., Goday, A., Damas-Fuentes, M., Belzer, C., Martínez-Gonzalez, M. Á., Hu, F. B., & Salas-Salvadó, J. (2022). Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome. Frontiers in Nutrition, 9, 976547. https://doi.org/10.3389/fnut.2022.976547
  4. Bajaj, J. S., Gavis, E. A., Fagan, A., Wade, J. B., Thacker, L. R., Fuchs, M., Patel, S., Davis, B., Meador, J., Puri, P., Sikaroodi, M., & Gillevet, P. M. (2021). A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder. Hepatology, 73(5), 1688–1700. https://doi.org/10.1002/hep.31496.
  5. Barton, W., Penney, N. C., Cronin, O., Garcia-Perez, I., Molloy, M. G., Holmes, E., Shanahan, F., Cotter, P. D., & O’Sullivan, O. (2017). The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut, gutjnl-2016-313627. https://doi.org/10.1136/gutjnl-2016-313627
  6. Chahwan, B., Kwan, S., Isik, A., Van Hemert, S., Burke, C., & Roberts, L. (2019a). Gut feelings: A randomised, triple-blind, placebo-controlled trial of probiotics for depressive symptoms. Journal of Affective Disorders, 253, 317–326. https://doi.org/10.1016/j.jad.2019.04.097
  7. Christodoulou, E., Mpali, T., Dimitriadou, M.-E., & Koutelidakis, A. E. (2024). Mindfulness, Gut–Brain Axis, and Health-Related Quality of Life: The Paradigm of IBD Patients. Healthcare, 12(12), 1209. https://doi.org/10.3390/healthcare12121209
  8. Clarke, S. F., Murphy, E. F., O’Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O’Reilly, M., Jeffery, I. B., Wood-Martin, R., Kerins, D. M., Quigley, E., Ross, R. P., O’Toole, P. W., Molloy, M. G., Falvey, E., Shanahan, F., & Cotter, P. D. (2014). Exercise and associated dietary extremes impact on gut microbial diversity. Gut, 63(12), 1913–1920. https://doi.org/10.1136/gutjnl-2013-306541
  9. Cuevas-Sierra, A., Milagro, F. I., Aranaz, P., Martínez, J. A., & Riezu-Boj, J. I. (2021). Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population. Nutrients, 13(8), 2710. https://doi.org/10.3390/nu13082710
  10. De Jong, W. J., Cleveringa, A. M., Greijdanus, B., Meyer, P., Heineman, E., & Hulscher, J. B. (2015). The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial. Alcohol, 49(1), 65–70. https://doi.org/10.1016/j.alcohol.2014.09.033
  11. Estaki, M., Langsetmo, L., Shardell, M., Mischel, A., Jiang, L., Zhong, Y., Kaufmann, C., Knight, R., Stone, K., & Kado, D. (2023). Association of Subjective and Objective Measures of Sleep With Gut Microbiota Composition and Diversity in Older Men: The Osteoporotic Fractures in Men Study. The Journals of Gerontology: Series A, 78(10), 1925–1932. https://doi.org/10.1093/gerona/glad011
  12. Estaki, M., Pither, J., Baumeister, P., Little, J. P., Gill, S. K., Ghosh, S., Ahmadi-Vand, Z., Marsden, K. R., & Gibson, D. L. (2016). Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions. Microbiome, 4(1), 42. https://doi.org/10.1186/s40168-016-0189-7
  13. Fan, J., Zhou, Y., Meng, R., Tang, J., Zhu, J., Aldrich, M. C., Cox, N. J., Zhu, Y., Li, Y., & Zhou, D. (2023). Cross-talks between gut microbiota and tobacco smoking: A two-sample Mendelian randomization study. BMC Medicine, 21(1), 163. https://doi.org/10.1186/s12916-023-02863-1.
  14. García-Gavilán, J. F., Atzeni, A., Babio, N., Liang, L., Belzer, C., Vioque, J., Corella, D., Fitó, M., Vidal, J., Moreno-Indias, I., Torres-Collado, L., Coltell, O., Toledo, E., Clish, C., Hernando, J., Yun, H., Hernández-Cacho, A., Jeanfavre, S., Dennis, C., … Salas-Salvadó, J. (2024). Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: A randomized clinical trial. The American Journal of Clinical Nutrition, 119(5), 1143–1154. https://doi.org/10.1016/j.ajcnut.2024.02.021
  15. Gaylord, S. A., Palsson, O. S., Garland, E. L., Faurot, K. R., Coble, R. S., Mann, D. J., Frey, W., Leniek, K., & Whitehead, W. E. (2011). Mindfulness Training Reduces the Severity of Irritable Bowel Syndrome in Women: Results of a Randomized Controlled Trial. American Journal of Gastroenterology, 106(9), 1678–1688. https://doi.org/10.1038/ajg.2011.184
  16. Grosicki, G. J., Riemann, B. L., Flatt, A. A., Valentino, T., & Lustgarten, M. S. (2020). Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: A pilot study. Sleep Medicine, 73, 76–81. https://doi.org/10.1016/j.sleep.2020.04.013
  17. Guevara‐Cruz, M., Flores‐López, A. G., Aguilar‐López, M., Sánchez‐Tapia, M., Medina‐Vera, I., Díaz, D., Tovar, A. R., & Torres, N. (2019). Improvement of Lipoprotein Profile and Metabolic Endotoxemia by a Lifestyle Intervention That Modifies the Gut Microbiota in Subjects With Metabolic Syndrome. Journal of the American Heart Association, 8(17), e012401. https://doi.org/10.1161/JAHA.119.012401
  18. Holzhausen, E. A., Peppard, P. E., Sethi, A. K., Safdar, N., Malecki, K. C., Schultz, A. A., Deblois, C. L., & Hagen, E. W. (2024). Associations of gut microbiome richness and diversity with objective and subjective sleep measures in a population sample. SLEEP, 47(3), zsad300. https://doi.org/10.1093/sleep/zsad300
  19. Kazemi, A., Noorbala, A. A., Azam, K., Eskandari, M. H., & Djafarian, K. (2019). Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clinical Nutrition, 38(2), 522–528. https://doi.org/10.1016/j.clnu.2018.04.010
  20. Kim, C.-S., Cha, L., Sim, M., Jung, S., Chun, W. Y., Baik, H. W., & Shin, D.-M. (2021). Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. The Journals of Gerontology: Series A, 76(1), 32–40. https://doi.org/10.1093/gerona/glaa090
  21. Kondo, Y., Hashimoto, Y., Hamaguchi, M., Kaji, A., Sakai, R., Inoue, R., Kashiwagi, S., Mizushima, K., Uchiyama, K., Takagi, T., Naito, Y., & Fukui, M. (2022). Effects of Smoking on the Gut Microbiota in Individuals with Type 2 Diabetes Mellitus. Nutrients, 14(22), 4800. https://doi.org/10.3390/nu14224800.
  22. Lankelma, J. M., Cranendonk, D. R., Belzer, C., De Vos, A. F., De Vos, W. M., Van Der Poll, T., & Wiersinga, W. J. (2017). Antibiotic-induced gut microbiota disruption during human endotoxemia: A randomised controlled study. Gut, 66(9), 1623–1630. https://doi.org/10.1136/gutjnl-2016-312132
  23. Leyrolle, Q., Cserjesi, R., D.G.H. Mulders, M., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Portheault, D., Amadieu, C., Bindels, L. B., Leclercq, S., Rodriguez, J., Neyrinck, A. M., Cani, P. D., Lanthier, N., Trefois, P., Bindelle, J., Paquot, N., Cnop, M., Thissen, J.-P., … Delzenne, N. M. (2021). Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial. Brain, Behavior, and Immunity, 94, 289–298. https://doi.org/10.1016/j.bbi.2021.01.014
  24. Liu, M., Tandorost, A., Moludi, J., & Dey, P. (2023). Prebiotics Plus Probiotics May Favorably Impact on Gut Permeability, Endocannabinoid Receptors, and Inflammatory Biomarkers in Patients with Coronary Artery Diseases: A Clinical Trial. Food Science & Nutrition, fsn3.3835. https://doi.org/10.1002/fsn3.3835
  25. Madan, A., Thompson, D., Fowler, J. C., Ajami, N. J., Salas, R., Frueh, B. C., Bradshaw, M. R., Weinstein, B. L., Oldham, J. M., & Petrosino, J. F. (2020). The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness. Journal of Affective Disorders, 264, 98–106. https://doi.org/10.1016/j.jad.2019.12.020
  26. Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., Patil, K. R., Bork, P., & Typas, A. (2018). Extensive impact of non-antibiotic drugs on human gut bacteria. Nature, 555(7698), 623–628. https://doi.org/10.1038/nature25979
  27. Mikkelsen, K. H., Frost, M., Bahl, M. I., Licht, T. R., Jensen, U. S., Rosenberg, J., Pedersen, O., Hansen, T., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2015). Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism. PLOS ONE, 10(11), e0142352. https://doi.org/10.1371/journal.pone.0142352
  28. O’Sullivan, O., Cronin, O., Clarke, S. F., Murphy, E. F., Molloy, M. G., Shanahan, F., & Cotter, P. D. (2015). Exercise and the microbiota. Gut Microbes, 6(2), 131–136. https://doi.org/10.1080/19490976.2015.1011875
  29. Papalini, S., Michels, F., Kohn, N., Wegman, J., Van Hemert, S., Roelofs, K., Arias-Vasquez, A., & Aarts, E. (2019). Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition. Neurobiology of Stress, 10, 100141. https://doi.org/10.1016/j.ynstr.2018.100141.
  30. Pickering, H., Hart, J. D., Burr, S., Stabler, R., Maleta, K., Kalua, K., Bailey, R. L., & Holland, M. J. (2022). Impact of azithromycin mass drug administration on the antibiotic-resistant gut microbiome in children: A randomized, controlled trial. Gut Pathogens, 14(1), 5. https://doi.org/10.1186/s13099-021-00478-6
  31. Reyman, M., Van Houten, M. A., Watson, R. L., Chu, M. L. J. N., Arp, K., De Waal, W. J., Schiering, I., Plötz, F. B., Willems, R. J. L., Van Schaik, W., Sanders, E. A. M., & Bogaert, D. (2022). Effects of early-life antibiotics on the developing infant gut microbiome and resistome: A randomized trial. Nature Communications, 13(1), 893. https://doi.org/10.1038/s41467-022-28525-z
  32. Rinott, E., Meir, A. Y., Tsaban, G., Zelicha, H., Kaplan, A., Knights, D., Tuohy, K., Scholz, M. U., Koren, O., Stampfer, M. J., Wang, D. D., Shai, I., & Youngster, I. (2022). The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: A randomized controlled trial. Genome Medicine, 14(1), 29. https://doi.org/10.1186/s13073-022-01015-z
  33. Roager, H. M., Vogt, J. K., Kristensen, M., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., … Licht, T. R. (2019). Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: A randomised cross-over trial. Gut, 68(1), 83–93. https://doi.org/10.1136/gutjnl-2017-314786
  34. Sousa, K. T. D., Marques, E. S., Levy, R. B., & Azeredo, C. M. (2020). Food consumption and depression among Brazilian adults: Results from the Brazilian National Health Survey, 2013. Cadernos de Saúde Pública, 36(1), e00245818. https://doi.org/10.1590/0102-311x00245818
  35. Sublette, M. G., Cross, T.-W. L., Korcarz, C. E., Hansen, K. M., Murga-Garrido, S. M., Hazen, S. L., Wang, Z., Oguss, M. K., Rey, F. E., & Stein, J. H. (2020). Effects of Smoking and Smoking Cessation on the Intestinal Microbiota. Journal of Clinical Medicine, 9(9), 2963. https://doi.org/10.3390/jcm9092963
  36. Wauters, L., Van Oudenhove, L., Accarie, A., Geboers, K., Geysen, H., Toth, J., Luypaerts, A., Verbeke, K., Smokvina, T., Raes, J., Tack, J., & Vanuytsel, T. (2022). Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: A randomized placebo-controlled trial. Gut Microbes, 14(1), 2031695. https://doi.org/10.1080/19490976.2022.2031695
  37. Williams, E. A., Stimpson, J., Wang, D., Plummer, S., Garaiova, I., Barker, M. E., & Corfe, B. M. (2009). Clinical trial: A multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double‐blind placebo‐controlled study. Alimentary Pharmacology & Therapeutics, 29(1), 97–103. https://doi.org/10.1111/j.1365-2036.2008.03848.x
  38. Worthley, D. L., Le Leu, R. K., Whitehall, V. L., Conlon, M., Christophersen, C., Belobrajdic, D., Mallitt, K.-A., Hu, Y., Irahara, N., Ogino, S., Leggett, B. A., & Young, G. P. (2009). A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: Effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. The American Journal of Clinical Nutrition, 90(3), 578–586. https://doi.org/10.3945/ajcn.2009.28106
  39. Xia, Y., Wang, N., Yu, B., Zhang, Q., Liu, L., Meng, G., Wu, H., Du, H., Shi, H., Guo, X., Liu, X., Li, C., Han, P., Dong, R., Wang, X., Bao, X., Su, Q., Gu, Y., Fang, L., … Niu, K. (2017). Dietary patterns are associated with depressive symptoms among Chinese adults: A case–control study with propensity score matching. European Journal of Nutrition, 56(8), 2577–2587. https://doi.org/10.1007/s00394-016-1293-y
  40. Zernicke, K. A., Campbell, T. S., Blustein, P. K., Fung, T. S., Johnson, J. A., Bacon, S. L., & Carlson, L. E. (2013). Mindfulness-Based Stress Reduction for the Treatment of Irritable Bowel Syndrome Symptoms: A Randomized Wait-list Controlled Trial. International Journal of Behavioral Medicine, 20(3), 385–396. https://doi.org/10.1007/s12529-012-9241-6

Introduction: The intricate relationship between lifestyle factors and gut health has become a focus of recent research, emphasizing the significant role of the gut-brain axis (GBA) in regulating both physical and emotional well- being. Unhealthy lifestyle choices, including a diet high in ultra-processed foods, irregular sleep patterns, physical inactivity, and substance abuse, have been closely associated with gut dysbiosis, leading to gastrointestinal (GI) symptoms and mood disturbances such as anxiety and depression. The gut microbiota, through the production of neurotransmitters like serotonin and dopamine, as well as short-chain fatty acids (SCFAs), influences mood and mental health via the GBA. Maintaining a healthy lifestyle, characterized by balanced nutrition, regular physical activity, and good sleep quality, is critical in fostering a diverse and stable gut microbiome, which in turn supports emotional stability.  Aim: This review aims to examine the existing literature on the impact of lifestyle factors, such as diet, physical activity, sleep, smoking, alcohol consumption, and stress management, on gut health and emotional well-being. The goal is to highlight the importance of gut microbiota in mental health and the potential therapeutic strategies to enhance gut health for improved emotional outcomes.  Methodology: A comprehensive search of peer-reviewed journal articles was conducted using databases such as PubMed, Google Scholar, and Web of Science. Keywords like "lifestyle," "gut health," "emotional well-being," "dietary habits," "physical activity," "sleep patterns," and "gut-brain axis" were used to identify relevant studies. Inclusion criteria focused on human clinical trials and observational studies published within the last 16 years. Studies involving animal subjects, non-peer- reviewed articles, and outdated research were excluded.  Results: The literature shows that diets high in fiber and low in processed foods support a healthier gut microbiome, while high consumption of ultra-processed foods disrupts gut bacteria, leading to GI symptoms and mood disorders. Regular physical activity was found to enhance gut microbiota diversity, contributing to better emotional well-being. Conversely, poor sleep quality and chronic stress were linked to gut dysbiosis, which exacerbated mood disturbances. Smoking and excessive alcohol consumption further damaged gut health, contributing to mood dysregulation. Probiotic and prebiotic interventions, particularly synbiotics, were found to restore gut balance and improve both GI and mental health outcomes.  Conclusion: This review underscores the pivotal role of lifestyle choices in shaping gut health and emotional well-being. A balanced diet, regular exercise, sufficient sleep, and stress management are essential for maintaining a healthy gut microbiome, which, in turn, supports emotional stability. Therapeutic strategies involving prebiotics, probiotics, and synbiotics offer promising avenues for improving both gut health and mood. Addressing lifestyle factors and promoting gut health can potentially serve as an effective approach for enhancing overall well-being and preventing mood disorders.

Keywords : Gut-Brain Axis, Gut Health, Lifestyle Factors, Emotional Well-Being, Diet, Physical Activity, Probiotics, Prebiotics.

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