The role of UDCA in gallstones resolution
has been widely debated and it is still a longstanding
primary treatment of this syndrome. We explored on 20
patients both sex, randomly assigned, the feasibility,
advantages, and drawbacks of intravenous high UDCA
dosages intravenous perfusion compared with the same
amount of bile salt oral delivery.
The primary clinical endpoint was stones
disappearance and the surrogate endpoint was the
relieve of colicky pain symptoms and liver enzymes
Notwithstanding the bias due to small cases
number, the evidence is definitely in favor of parenteral
treatment which is very effective especially in the acute
control of pain, vomitus and nausea, when oral drugs
and feeding is not advisable.