Authors :
Sonia Nain; Rashi Datten
Volume/Issue :
Volume 11 - 2026, Issue 8 - August
Google Scholar :
https://tinyurl.com/2vc4z97e
Scribd :
https://tinyurl.com/4bdm72t4
DOI :
https://doi.org/10.38124/ijisrt/26aug027
Note : A published paper may take 4-5
working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and
ResearchGate.
Abstract :
Global food security is increasingly challenged by climate change, rapid population growth, declining
agricultural resources, and the emergence of new plant diseases, necessitating innovative and sustainable agricultural
solutions. Molecular biology has transformed crop science through advances in genomics, gene editing, molecular
diagnostics, and functional genomics, enabling a deeper understanding of plant traits and stress responses.
Simultaneously, Artificial Intelligence (AI) has emerged as a powerful computational tool capable of processing complex
biological datasets, predicting crop performance, identifying disease patterns, and supporting precision agricultural
decision-making. This review explores the integration of molecular biology and AI as a unified approach to enhancing
sustainable food security. It examines how machine learning, deep learning, computer vision, and bioinformatics
complement molecular techniques to accelerate crop improvement, optimize resource utilization, improve disease
surveillance, and strengthen climate-resilient agricultural systems. The paper further discusses recent advancements,
practical applications, existing challenges, ethical considerations, and future research opportunities associated with AI
driven molecular agriculture. In addition, a conceptual AI–Molecular Biology Integration Framework is proposed to
illustrate the systematic interaction between biological data acquisition, intelligent analytics, predictive modelling, and
sustainable agricultural implementation. The review highlights that combining molecular biology with AI has the potential
to improve productivity, resource efficiency, and environmental sustainability while supporting resilient food production
systems. This interdisciplinary approach offers valuable insights for researchers, policymakers, and agricultural
stakeholders seeking to develop intelligent and sustainable strategies for future global food security.
Keywords :
Sustainable Food Security, Molecular Biology, Artificial Intelligence, Machine Learning, Genomics, Bioinformatics, Precision Agriculture, Crop Improvement, Climate-Resilient Agriculture, Intelligent Farming.
References :
- D. K. Pandey and R. Mishra, “Towards sustainable agriculture: Harnessing AI for global food security,” Artificial Intelligence in Agriculture, vol. 12, pp. 72–84, Apr. 2024.
- M. M. Fareed and S. Shityakov, “Artificial intelligence-enabled foodomics: Integrating multi-omics, personalized drug discovery, nutrition, and sustainable food systems,” In Silico Research in Biomedicine, vol. 2, Art. no. 100378, 2026.
- N. Prashar, S. Kapil, A. Sharma, V. Sharma, P. Bagga, A. Saini, et al., “Edible insect nutrition and bioinformatics based nutritional assessment,” Exploration of Foods and Foodomics, vol. 4, Art. no. 1010149, 2026.
- M. A. Mir, N. Zaidi, S. K. Chang, N. Abdelli, and K. Andrews, “Artificial intelligence applications in food science: A review of cutting-edge technologies,” Cogent Food & Agriculture, vol. 12, no. 1, Art. no. 2606439, 2026.
- A. Nayak and D. Dutta, “A comprehensive review on CRISPR and artificial intelligence based emerging food packaging technology to ensure ‘safe food’,” Sustainable Food Technology, vol. 1, pp. 641–657, 2023.
- C. Katam, H. Maqsood, B. Bucci, and S. Chen, “Next-Generation Sustainable Food Production Through Integrative Biotechnology, AI, and Climate-Resilient Innovations,” Food and Energy Security, vol. 15, Art. no. e70252, 2026.
- H. Wu, M. Luo, Y. Liu, J. Yang, and Y. Cao, “Integrated biotechnological and artificial intelligence innovations for plant improvement,” Frontiers in Plant Science, vol. 16, Art. no. 1736707, 2025.
- A. Ahmad, A. X. W. Liew, F. Venturini, A. Kalogeras, A. Candiani, G. Di Benedetto, et al., “AI can empower agriculture for global food security: Challenges and prospects in developing nations,” Frontiers in Artificial Intelligence, vol. 7, Art. no. 1328530, 2024.
- N. Alkalbani, L. Shahin, H. Benzeghiba, R. S. Obaid, T. M. Osaili, L. Cheik Ismail, et al., “Artificial intelligence in functional food innovation: Bioactive enhancement and formulation optimization: A quasi-systematic review,” Food Chemistry: X, vol. 34, Art. no. 103628, 2026.
- A. Tyczewska, T. Twardowski, and E. Woźniak-Gientka, “Agricultural biotechnology for sustainable food security,” Trends in Biotechnology, vol. 41, no. 1, pp. 1–5, 2023.
- K. Wang, L. Xia, X. Yang, C. Du, T. Tang, Z. Yang, et al., “Integrating Artificial Intelligence and Biotechnology to Enhance Cold Stress Resilience in Legumes,” Plants, vol. 14, Art. no. 2784, 2025.
- A. Ayoub, “Integration of Artificial Intelligence in Food Processing Technologies,” Processes, vol. 14, Art. no. 513, 2026.
- R. M. S. R. Chamara, S. M. P. Senevirathne, S. A. I. L. N. Samarasinghe, M. W. R. C. Premasiri, K. H. C. Sandaruwani, D. M. N. N. Dissanayake, et al., “Role of artificial intelligence in achieving global food security: A promising technology for future,” Sri Lanka Journal of Food and Agriculture, vol. 6, no. 2, pp. 43–70, 2020.
- S. Harshitha and R. Sandhu, “Next-Generation Breeding: Integrating Multi-Omics and Artificial Intelligence for Advancing Nutritional and Food Security,” Plant Cell Biotechnology and Molecular Biology, vol. 27, no. 3–4, pp. 216–236, 2026.
Global food security is increasingly challenged by climate change, rapid population growth, declining
agricultural resources, and the emergence of new plant diseases, necessitating innovative and sustainable agricultural
solutions. Molecular biology has transformed crop science through advances in genomics, gene editing, molecular
diagnostics, and functional genomics, enabling a deeper understanding of plant traits and stress responses.
Simultaneously, Artificial Intelligence (AI) has emerged as a powerful computational tool capable of processing complex
biological datasets, predicting crop performance, identifying disease patterns, and supporting precision agricultural
decision-making. This review explores the integration of molecular biology and AI as a unified approach to enhancing
sustainable food security. It examines how machine learning, deep learning, computer vision, and bioinformatics
complement molecular techniques to accelerate crop improvement, optimize resource utilization, improve disease
surveillance, and strengthen climate-resilient agricultural systems. The paper further discusses recent advancements,
practical applications, existing challenges, ethical considerations, and future research opportunities associated with AI
driven molecular agriculture. In addition, a conceptual AI–Molecular Biology Integration Framework is proposed to
illustrate the systematic interaction between biological data acquisition, intelligent analytics, predictive modelling, and
sustainable agricultural implementation. The review highlights that combining molecular biology with AI has the potential
to improve productivity, resource efficiency, and environmental sustainability while supporting resilient food production
systems. This interdisciplinary approach offers valuable insights for researchers, policymakers, and agricultural
stakeholders seeking to develop intelligent and sustainable strategies for future global food security.
Keywords :
Sustainable Food Security, Molecular Biology, Artificial Intelligence, Machine Learning, Genomics, Bioinformatics, Precision Agriculture, Crop Improvement, Climate-Resilient Agriculture, Intelligent Farming.