Authors :
Dr. Disha R Rai; Dr. Bhargavi; Dr. Abhijith Shetty; Dr Misha Rose Mathew; Dr. Nagarathna
Volume/Issue :
Volume 7 - 2022, Issue 3 - March
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3NAwMEV
DOI :
https://doi.org/10.5281/zenodo.6403769
Abstract :
Inflammasome is a multiprotein complex that
consists of a PRR- an adaptor protein or ASC [apoptosisrelated speck-like protein containing a CARD (caspase
activation and recruitment domain )] an active form of
caspase-1.Active caspase-1 subsequently processes the
leaderless proinflammatory cytokines pro L-1b and proIL-18, which are unconventionally secreted on caspase-1
cleavage. Therefore, inflammasome-mediated processing
and secretion of pro-IL-1b and pro-IL-18 enables a rapid,
yet tightly regulated and highly inducible
proinflammatory response. In addition to cytokine
secretion, inflammasome activation can also trigger an
inflammatory cell death dubbed pyroptosis, which serves
to blunt intracellular pathogen replication.
Keywords :
Inflammasomes, Caspase, Pyroptosis
Inflammasome is a multiprotein complex that
consists of a PRR- an adaptor protein or ASC [apoptosisrelated speck-like protein containing a CARD (caspase
activation and recruitment domain )] an active form of
caspase-1.Active caspase-1 subsequently processes the
leaderless proinflammatory cytokines pro L-1b and proIL-18, which are unconventionally secreted on caspase-1
cleavage. Therefore, inflammasome-mediated processing
and secretion of pro-IL-1b and pro-IL-18 enables a rapid,
yet tightly regulated and highly inducible
proinflammatory response. In addition to cytokine
secretion, inflammasome activation can also trigger an
inflammatory cell death dubbed pyroptosis, which serves
to blunt intracellular pathogen replication.
Keywords :
Inflammasomes, Caspase, Pyroptosis
