Authors : Joseph Oluwaseun Odewade; Lydia Oluwatosin Odewade

Volume/Issue : Volume 8 - 2023, Issue 6 - June

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/5ejhsfkd

DOI : https://doi.org/10.5281/zenodo.8047077

Abstract : Gastrointestinal infections are a frequent cause of illness given the high global morbidity rate. This study examined the in vitro assessment of Chrysophyllum albidum stem bark extract against bacterial strains implicated in gastrointestinal infections. The antibacterial potentials of the fractions of Chrysophyllum stem bark extract were assessed using agar diffusion and dilution methods, time kill assay, potassium ions leakage and nucleotides leakage. The chemical constituents present in the fractions were determined using Fourier Transform Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectrometry (GC-MS). Similar trends of reactions were observed when the concentrations of the fractions were increased to 2 x MIC and 3 x MIC. The FTIR and GC-MS results showed that the compounds that were present in the fractions were biologically active. This study demonstrated significant biocidal potentials of Chrysophyllum albidum stem bark extract against bacterial strains implicated in gastrointestinal infections.

Keywords : Gastrointestinal Infections, Chrysophyllum Albidum, Antibacterial Potentials, Time Kill Assay, Gas Chromatography -Mass Spectrometry.