Authors :
Amany Mudawy Albashir; Amira Siddig; Sara Abdel mahmoud
Volume/Issue :
Volume 9 - 2024, Issue 12 - December
Google Scholar :
https://tinyurl.com/ynumtm6c
Scribd :
https://tinyurl.com/2s3yzkj4
DOI :
https://doi.org/10.5281/zenodo.14576707
Abstract :
Background:
Male factors contribute for 40%–50% of cases of
infertility, which affects 8%–12% of the world's
population. Macro and trace components found in human
seminal plasma are essential for the health and normal
function of semen. Magnesium and cadmium levels in
seminal plasma were measured as part of this study's
attempt to connect these levels with male fertility.
Objectives:
To determine the Impact of Seminal Plasma Trace
Elements Magnesium and Cadmium ' on Seminal
Parameters among Infertile Sudanese Males in Khartoum
State-Sudan.
Methods:
Between November 2021 and April 2022, all semen
samples utilized in this comparative cross-sectional case-
control study were collected from willing patients visiting
Banoon and Ashmeeg Fertility Centres in Khartoum
state. Males who had been diagnosed as infertile made up
the study's case group (n = 150), while healthy males
whose fertility had been established by prior successful
fertility centers made up the study's control group (n =
150). The Buck model 210 VGP atomic absorption
spectrophotometer was used to estimate the
concentrations of TEs magnesium and cadmium. The
SPSS version 23 was used for all analyses, in depended t
testing was used to compare parameters between case and
control and person correlation for correlate magnesium
and cadmium with seminal analysis parameter . A P-value
of 0.05 or lower was deemed statistically significant.
Results:
Seminal cadmium levels were significantly greater
and magnesium levels were lower in infertile men (p.
value 0.000). Magnesium was found to have a strong
negative association with semen volume (r=-.266 with
p=0.008) and a substantial positive correlation with sperm
count and motility (r=.994 and.216 with p=0.01 and 0.03).
However, there was a negative connection between
morphology and cadmium (r=-.362; p = 0.10).
Conclusion:
According to the current study's findings, we
conclude that, infertile men have high cadmium and low
magnesium. Low magnesium has a direct impact on
sperm count, sperm motility, and semen volume
Conversely, sperm morphology is directly impacted by
elevated cadmium.
References :
- Alahmar, A. Effect of Vitamin C, Vitamin E, zinc, selenium, and coenzyme Q10 in infertile men with idiopathic oligoasthenozoospermia. Int. J. Infertil. Fetal. Med. 2017; 8, 45–49
- Kasperczyk, A., Dobrakowski, M., Horak, S., Zalejska-Fiolka, J., Birkner, E. The influence of macro and trace elements on sperm quality. J. Trace Elem. Med Biol. 2015; 30, 153–159
- Showell, M.J., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M.T., Hart, R.J., Antioxidants for male subfertility. Cochrane Database Syst. Rev. 2014; 12.
- Wang, Y.X., Wang, P., Feng, W., et al., Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity. Environ. Pol. 2017; 224, 224–234.
- guzikowski w., szynkowska mi., motak-pochrzęst h., pawlaczyk A., sypniewski S. Trace elements in seminal plasma of men from infertile couples. Arch med sci: AMS. 2015; 11(3):591.
- wong wy., flik g., groenen pm., swinkels dw., thomas cm., copius-peereboom jh., et al. The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men. Reprod. Toxicol. 2001; 15(2):131-6.
- ryzen e., rude rk. Low intracellular magnesium in patients with acute pancreatitis and hypocalcemia. West J Med. 1990; 152(2):145.
- LU SY., HUANG ZM., HUANG WK., LIU XY., CHEN YY., SHI T., et al. How calcium inhibits the magnesium‐dependent kinase gsk3β: A molecular simulation study. Proteins: 2013; 81(5):740-53.
- el aaleba., abdo hm., elshahed ar., bayoumi im., hamdy mhm. Measuement of seminal and serum plasma magnesium levels in premature ejaculation. The Gulf Journal of Dermatology and Venereology (GJDV). 2012; 20(2):35-9.
- Omu AE, Al-Bader AA, Dashti H, Oriowo MA. Magnesium in human semen: possible role in premature ejaculation. Arch Androl. 2001; 46:59– 66.
- Jimenez T, McDermott JP, Sánchez G, Blanco G. Na,K-ATPase alpha4 isoform is essential for sperm fertility. Proc Natl Acad Sci U S A. 2011; 108:644– 9.
- Ilieva DM, Argirova M, Angelova LY, Gradinaru RV, Drochioiu G, Surleva AR. Application of chemical and biological tests for estimation of current state of a tailing dump and surrounding soil from the region of Tarnita, Suceava, Romania. Environ Sci Pollut Res Int. 2020; 27:1386–96.
- Maneesh M, Jayalekshmi H. Role of reactive oxygen species and antioxidants on pathophysiology of male reproduction. Indian J Clin Biochem. 2006; 21:80– 9.
- Hillary W, Julie WC, Edmund YK. Role of reactive oxygen species in male infertility: an updated review of literature. Arab J Urol. 2018; 16:35– 43.
- Examination and processing of human semen, WHO 2010 https://www.who.int
- Colagar AH, Marzony ET, Chaichi MJ. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009; 29:82– 8.
- F. Aljaser, H. Tabassum, S. Fatima et al. Effect of trace elements on the seminal oxidative status and correlation to sperm motility in infertile Saudi males. Saudi Journal of Biological Sciences 28 2021; 4455–4460.
- Ahmed Zaki1 , Fouad H. A.2 , Mostafa A. M.1 , Tarek M. E.3 , Ahmed W. A.4 Effects of Environmental Exposure to Lead and Cadmium on Male Fertility Mansoura J. Forens. Med. Clin. Toxicol., July. 2018; Vol. 26, No. 2,
- Ademola C. Famurewa, Emmanuel I. Ugwuja. Association of Blood and Seminal Plasma Cadmium and Lead Levels With Semen Quality in Non-Occupationally Exposed Infertile Men in Abakaliki, South East Nigeria Journal of Family and Reproductive Health .June 2017; Vol. 11, No. 2.
- Atig F, Raffa M, Habib B, Kerkeni A, Saad A, Ajina M. Impact of seminal trace element and glutathione levels on semen quality of Tunisian infertile men. BMC Urol 2012; 12: 6.
- Taha EA, Sayed SK, Ghandour NM, Mahran AM, Saleh MA, Amin MM, et al. Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males. Cent European J Urol 2013; 66: 84-92
22.Benoff S, Jacob A, Hurley IR. Male infertility and environmental exposure to lead and cadmium. Hum Reprod Update 2000; 6: 107-
Background:
Male factors contribute for 40%–50% of cases of
infertility, which affects 8%–12% of the world's
population. Macro and trace components found in human
seminal plasma are essential for the health and normal
function of semen. Magnesium and cadmium levels in
seminal plasma were measured as part of this study's
attempt to connect these levels with male fertility.
Objectives:
To determine the Impact of Seminal Plasma Trace
Elements Magnesium and Cadmium ' on Seminal
Parameters among Infertile Sudanese Males in Khartoum
State-Sudan.
Methods:
Between November 2021 and April 2022, all semen
samples utilized in this comparative cross-sectional case-
control study were collected from willing patients visiting
Banoon and Ashmeeg Fertility Centres in Khartoum
state. Males who had been diagnosed as infertile made up
the study's case group (n = 150), while healthy males
whose fertility had been established by prior successful
fertility centers made up the study's control group (n =
150). The Buck model 210 VGP atomic absorption
spectrophotometer was used to estimate the
concentrations of TEs magnesium and cadmium. The
SPSS version 23 was used for all analyses, in depended t
testing was used to compare parameters between case and
control and person correlation for correlate magnesium
and cadmium with seminal analysis parameter . A P-value
of 0.05 or lower was deemed statistically significant.
Results:
Seminal cadmium levels were significantly greater
and magnesium levels were lower in infertile men (p.
value 0.000). Magnesium was found to have a strong
negative association with semen volume (r=-.266 with
p=0.008) and a substantial positive correlation with sperm
count and motility (r=.994 and.216 with p=0.01 and 0.03).
However, there was a negative connection between
morphology and cadmium (r=-.362; p = 0.10).
Conclusion:
According to the current study's findings, we
conclude that, infertile men have high cadmium and low
magnesium. Low magnesium has a direct impact on
sperm count, sperm motility, and semen volume
Conversely, sperm morphology is directly impacted by
elevated cadmium.