Authors :
Nwaokocha SC; Gekpe CG; Ofem OE.; Ezeani Chidiebere
Volume/Issue :
Volume 9 - 2024, Issue 2 - February
Google Scholar :
https://tinyurl.com/mu6jwud7
Scribd :
https://tinyurl.com/ykzaznny
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24FEB084
Abstract :
Exposure to environmental toxins like Lead
has been associated with male infertility. Whether or not
potent antioxidants like omega 3 Fatty acids and/or
quercetin could reduce the effect of lead on male sexual
functions deserve scientific investigation. Thirty-five (35)
male albino Wistar rats were assigned into 7 groups:
Group 1 (normal control), Group 2 (sham-control1),
Group 3 (sham-control 2), Group 4 (Lead group), Group
5 (Lead + Omega-3), Group 6 (Lead + Quercetin) and
Group 7 (Lead + Omega-3 + Quercetin). Lead was given
orally at 20mg/kg bwt, quercetin 20mg/kg bwt s.c,
Omega-3 14.29mg/kg bwt orally. The animals all had
free access to rat food and water for 56 days. After which
they were sacrificed, and semen and blood samples were
collected for assay. The results showed no significant
difference between normal control group and sham
controls. Sperm function parameters (sperm count,
motile, viable and normal sperms) in the lead treated
group was significantly reduced compared to the control.
Omega 3 and/or quercetin administration reversed the
reductions in sperm function parameters to near control
levels. Hormone levels (LH and Testosterone) were
significantly reduced in lead group compared to the
normal control but were reversed after quercetin and
omega 3 treatment. However, there was no significant
difference in the FSH level among experimental groups.
Conclusively, omega 3 and/or quercetin ameliorates the
harmful effects of lead on reproductive parameters by
improving sperm functions (total sperm count, viability,
motility, and morphology). A combination of both
quercetin and omega 3 provided better ameliorative
effect than either omega 3 or quercetin.
Keywords :
Infertility, Quercetin, Omega 3, Lead, Sex Hormones, Rats.
Exposure to environmental toxins like Lead
has been associated with male infertility. Whether or not
potent antioxidants like omega 3 Fatty acids and/or
quercetin could reduce the effect of lead on male sexual
functions deserve scientific investigation. Thirty-five (35)
male albino Wistar rats were assigned into 7 groups:
Group 1 (normal control), Group 2 (sham-control1),
Group 3 (sham-control 2), Group 4 (Lead group), Group
5 (Lead + Omega-3), Group 6 (Lead + Quercetin) and
Group 7 (Lead + Omega-3 + Quercetin). Lead was given
orally at 20mg/kg bwt, quercetin 20mg/kg bwt s.c,
Omega-3 14.29mg/kg bwt orally. The animals all had
free access to rat food and water for 56 days. After which
they were sacrificed, and semen and blood samples were
collected for assay. The results showed no significant
difference between normal control group and sham
controls. Sperm function parameters (sperm count,
motile, viable and normal sperms) in the lead treated
group was significantly reduced compared to the control.
Omega 3 and/or quercetin administration reversed the
reductions in sperm function parameters to near control
levels. Hormone levels (LH and Testosterone) were
significantly reduced in lead group compared to the
normal control but were reversed after quercetin and
omega 3 treatment. However, there was no significant
difference in the FSH level among experimental groups.
Conclusively, omega 3 and/or quercetin ameliorates the
harmful effects of lead on reproductive parameters by
improving sperm functions (total sperm count, viability,
motility, and morphology). A combination of both
quercetin and omega 3 provided better ameliorative
effect than either omega 3 or quercetin.
Keywords :
Infertility, Quercetin, Omega 3, Lead, Sex Hormones, Rats.
