Authors :
Rodrigo Strehl Machado; Ygor Rocha Fernandes; Regis S Ferrelli; Silvio K Ogata
Volume/Issue :
Volume 8 - 2023, Issue 12 - December
Google Scholar :
http://tinyurl.com/38hn9tds
Scribd :
http://tinyurl.com/mf66yjz6
DOI :
https://doi.org/10.5281/zenodo.10441937
Abstract :
Background/Aims. Percutaneous endoscopic
gastrostomy (PEG) is frequently indicated in patients
with global developmental delay (GDD) with dysphagia.
The present study aims at evaluating the influence of
PEG on the GER and the gastric emptying of liquids in
children with GDD.
Methods. 16 children with GDD (6M/10F, median age 9
yrs [1 - 17]) with clinically indicated PEG were evaluated
with intraluminal impedance and pH monitoring and 13
C- acetate breath test (gastric emptying). Baseline and 5-
month values for esophageal acid exposure, bolus contact
time, number of reflux episodes and the gastric emptying
half- time were compared with paired t-test.
Results. The number of total reflux episodes raised after
PEG (mean 18.8, 95% CI 1 to 36.3, P = 0.038), mainly due
to an increase in weakly acid reflux episodes (mean
difference 16.7, 95% CI 6.5 - 27, P = 0.004). The variation
of the gastric emptying half- time was not significant at
five months (+7.9 min (95% CI -9.9 to 25.7), P = 0.348).
Conclusions. PEG placement did not affect the reflux
index, the bolus contact time, and the gastric emptying. A
slight increase in weakly acid reflux episodes without
clinical repercussion was observed.
Keywords :
Gastric Emptying; Breath Test; Cerebral Palsy; Gastrostomy;
Background/Aims. Percutaneous endoscopic
gastrostomy (PEG) is frequently indicated in patients
with global developmental delay (GDD) with dysphagia.
The present study aims at evaluating the influence of
PEG on the GER and the gastric emptying of liquids in
children with GDD.
Methods. 16 children with GDD (6M/10F, median age 9
yrs [1 - 17]) with clinically indicated PEG were evaluated
with intraluminal impedance and pH monitoring and 13
C- acetate breath test (gastric emptying). Baseline and 5-
month values for esophageal acid exposure, bolus contact
time, number of reflux episodes and the gastric emptying
half- time were compared with paired t-test.
Results. The number of total reflux episodes raised after
PEG (mean 18.8, 95% CI 1 to 36.3, P = 0.038), mainly due
to an increase in weakly acid reflux episodes (mean
difference 16.7, 95% CI 6.5 - 27, P = 0.004). The variation
of the gastric emptying half- time was not significant at
five months (+7.9 min (95% CI -9.9 to 25.7), P = 0.348).
Conclusions. PEG placement did not affect the reflux
index, the bolus contact time, and the gastric emptying. A
slight increase in weakly acid reflux episodes without
clinical repercussion was observed.
Keywords :
Gastric Emptying; Breath Test; Cerebral Palsy; Gastrostomy;
