Authors : Simranjit Singh

Volume/Issue : Volume 10 - 2025, Issue 12 - December

Google Scholar : https://tinyurl.com/3ajtu832

Scribd : https://tinyurl.com/2z3x8zk5

DOI : https://doi.org/10.38124/ijisrt/25dec1254

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Central corneal thickness (CCT) is an important parameter in ophthalmology as it affects the intraocular pressure measurement and the refractive surgery outcome, and it is a possible biomarker for a number of ocular conditions. Omega- 3 polyunsaturated fatty acid (PUFAs), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has come into importance as modulators of ocular health for its anti-inflammatory action as well as structural components of cellular membranes. This paper reviews the relationship between omega-3 fatty acid supplementation and CCT and possible mechanisms such as modulation of inflammatory pathways, tear film stabilization and impact on corneal hydration. Current evidence for omega-3 supplementation on CCT has suggested that it may have an effect on CCT through an indirect mechanism stemming from the control of dry eye disease and maintenance of corneal surface health, but the direct causal relationship(s) need to be researched further.

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