Authors :
Nwauche, K.T.; Acho, E.S.; Okari, K.A.
Volume/Issue :
Volume 9 - 2024, Issue 3 - March
Google Scholar :
https://tinyurl.com/bhn562th
Scribd :
https://tinyurl.com/2ecrxd6t
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAR274
Abstract :
The impact of the ethanol extract of the plant
on kidney function markers of Testosterone propionate
induced prostatitis were studied and the PSA level of the
male wistar rats used was also studied. Thirty male wistar
rats were grouped into six groups (group1-6) of five rats
each. Normal water and the rat feeds were given to rats in
group 1 ad libitum and they were not treated. Prostatitis
was induced to the rats in groups 2 to 6 for four days after
which treatment commenced for 28 days. The reference
drug (Contiflo XL (400μg)) was administered to Group 3,
the rats in groups 4 and 5 received 100mg and 200mg of
the plant extract respectively while group 6 were
administered a combined dose of 100mg of plant extract
and contiflo XL. Qualitative phytochemical analysis of the
plant leaf revealed the presence of polyphenols (+++),
alkaloids (+++), saponins (++), tannins (++) and
flavonoids (+). The PSA Level that was observed to be
increased after induction of prostatitis in group2 was
significantly decreased when 200mg of the leaf ethanol
extract of the plant was administered to group 4. The
other groups (3, 5 and 6) were also decreased when
compared to group 2. For all the kidney function
biomarkers analyzed, a significant increase was observed
in group2 when compared with group 1. After the period
of treatment, urea, creatinine and the electrolytes (Na+
,
Cl-
, K+
and HCO3
-
) were observed to be significantly
decreased when 100mg of the extract was administered
showing the much potency it has in the disease
management except for bicarbonate where 200mg of the
extract had more potency. This study has revealed that
the plant leaf ethanol extract is suitable for the
management of prostatitis and has ameliorative effect on
the kidney function biomarkers of male wistar rats
induced with prostatitis.
Keywords :
Testosterone Propionate, Lasianthera Africana, Kidney, Prostatitis.
The impact of the ethanol extract of the plant
on kidney function markers of Testosterone propionate
induced prostatitis were studied and the PSA level of the
male wistar rats used was also studied. Thirty male wistar
rats were grouped into six groups (group1-6) of five rats
each. Normal water and the rat feeds were given to rats in
group 1 ad libitum and they were not treated. Prostatitis
was induced to the rats in groups 2 to 6 for four days after
which treatment commenced for 28 days. The reference
drug (Contiflo XL (400μg)) was administered to Group 3,
the rats in groups 4 and 5 received 100mg and 200mg of
the plant extract respectively while group 6 were
administered a combined dose of 100mg of plant extract
and contiflo XL. Qualitative phytochemical analysis of the
plant leaf revealed the presence of polyphenols (+++),
alkaloids (+++), saponins (++), tannins (++) and
flavonoids (+). The PSA Level that was observed to be
increased after induction of prostatitis in group2 was
significantly decreased when 200mg of the leaf ethanol
extract of the plant was administered to group 4. The
other groups (3, 5 and 6) were also decreased when
compared to group 2. For all the kidney function
biomarkers analyzed, a significant increase was observed
in group2 when compared with group 1. After the period
of treatment, urea, creatinine and the electrolytes (Na+
,
Cl-
, K+
and HCO3
-
) were observed to be significantly
decreased when 100mg of the extract was administered
showing the much potency it has in the disease
management except for bicarbonate where 200mg of the
extract had more potency. This study has revealed that
the plant leaf ethanol extract is suitable for the
management of prostatitis and has ameliorative effect on
the kidney function biomarkers of male wistar rats
induced with prostatitis.
Keywords :
Testosterone Propionate, Lasianthera Africana, Kidney, Prostatitis.
