Authors :
Ebenezer Adeola Ashamu; Jacob Ehiagwina Ataman; Christopher Sakpa; Folorunso Kolade Pelumi
Volume/Issue :
Volume 8 - 2023, Issue 9 - September
Google Scholar :
https://tinyurl.com/y7r5fxxz
Scribd :
https://tinyurl.com/4z34fnbc
DOI :
https://doi.org/10.5281/zenodo.10002651
Abstract :
Background:
Male reproductive health is a pivotal component of
overall well-being, and its susceptibility to environmental
factors, including plant extracts, necessitates thorough
investigation. Datura stramonium, commonly known as
jimsonweed, is renowned for its medicinal properties, yet
its influence on male reproductive parameters remains
inadequately explored.This study scrutinized the impact of Datura
stramonium extract (DSE) on male reproductive
parameters in adult male Wistar rats. DSE was derived
from the plant's seeds via methanol extraction. Forty-
nine rats were distributed into seven groups, receiving
50, 100 and 200 mg/kg DSE doses for 56 days, with some
groups undergoing withdrawal for an additional 28 days.Result:
Proximate analysis unveiled DSE's composition.
The investigation encompassed alterations in body
weight, epididymis weight, hormone levels (FSH, LH,
PRL, PRG, estrogen, testosterone), and semen quality
and morphology. Furthermore, histological evaluations
of the epididymis were conducted.Proximate analysis delineated DSE's composition.
Administration of diverse DSE doses significantly
perturbed body weight, epididymis weight, and
hormonal levels, affecting Follicle Stimulating Hormone
(FSH), Luteinizing Hormone (LH), testosterone, and
others. Semen analysis exposed changes in sperm count,
motility, and morphology. Remarkably, some effects
were ameliorated upon DSE withdrawal. Histological
examinations authenticated structural modifications in
the epididymides, paralleling the functional alterations
observed.
In conclusion, Datura stramonium seed extract
(DSE) considerably impaired male reproductive
parameters, yet withdrawal exhibited partial recovery.Subsequent research is imperative for comprehending
the enduring repercussions on reproductive health.
Keywords :
Epididymis, Datura stramonium Extract, Hormonal Imbalance, Semen Quality, Withdrawal Effects
Background:
Male reproductive health is a pivotal component of
overall well-being, and its susceptibility to environmental
factors, including plant extracts, necessitates thorough
investigation. Datura stramonium, commonly known as
jimsonweed, is renowned for its medicinal properties, yet
its influence on male reproductive parameters remains
inadequately explored.This study scrutinized the impact of Datura
stramonium extract (DSE) on male reproductive
parameters in adult male Wistar rats. DSE was derived
from the plant's seeds via methanol extraction. Forty-
nine rats were distributed into seven groups, receiving
50, 100 and 200 mg/kg DSE doses for 56 days, with some
groups undergoing withdrawal for an additional 28 days.Result:
Proximate analysis unveiled DSE's composition.
The investigation encompassed alterations in body
weight, epididymis weight, hormone levels (FSH, LH,
PRL, PRG, estrogen, testosterone), and semen quality
and morphology. Furthermore, histological evaluations
of the epididymis were conducted.Proximate analysis delineated DSE's composition.
Administration of diverse DSE doses significantly
perturbed body weight, epididymis weight, and
hormonal levels, affecting Follicle Stimulating Hormone
(FSH), Luteinizing Hormone (LH), testosterone, and
others. Semen analysis exposed changes in sperm count,
motility, and morphology. Remarkably, some effects
were ameliorated upon DSE withdrawal. Histological
examinations authenticated structural modifications in
the epididymides, paralleling the functional alterations
observed.
In conclusion, Datura stramonium seed extract
(DSE) considerably impaired male reproductive
parameters, yet withdrawal exhibited partial recovery.Subsequent research is imperative for comprehending
the enduring repercussions on reproductive health.
Keywords :
Epididymis, Datura stramonium Extract, Hormonal Imbalance, Semen Quality, Withdrawal Effects
