Hyperhomocysteinemia and Pregnancy: About a Case and Literature Review


Authors : Allae Eddine BOUCHAIB; Mamadou Alpha BALDE; Abdellah BABAHABIB; Moulay El Mehdi ELHASSANI; Jaouad KOUACH

Volume/Issue : Volume 8 - 2023, Issue 1 - January

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3XjSNM1

DOI : https://doi.org/10.5281/zenodo.7633006

Homocysteine (Hct) is a substance produced in the metabolism of methionine that can be found in our daily diet. The mutation of the methylenetetrahydrofolate reductase gene, especially for women with low folate intake. Hyperhomocysteinemia (HHct) can be due to several factors, such as a lack of folic acid, a deficiency in vitamins B6 and B12, hypothyroidism, medications, genetic anomalies, aging, and renal dysfunction. Increased homocysteine levels in peripheral blood can lead to vascular diseases, coronary artery dysfunction, atherosclerotic changes, and embolic diseases. As a result, increased thrombogenicity in pregnant women upstream of the trophoblast plug, leading to clot formation and early or late abortion. Recent studies have reported that hyperhomocysteinemia is associated with many pregnancy complications, including abortive disease, preeclampsia, premature delivery, retroplacental hematoma, fetal growth restriction, and gestational diabetes. Therefore, to prevent thrombosis, treatment relies on anticoagulants, sometimes combined with low-dose aspirin, especially for its anticoagulant effect. In this article, we report a case of a patient with a history of abortive disease on hyperhomocysteinemia who had a full-term pregnancy, while reminding the metabolism of homocysteine, its impact on pregnancy, and the interest in prescribing folic acid to avoid complications related to hyperhomocysteinemia

Keywords : Hyperhomocysteinemia, Pregnancy, Abortive Disease, Thrombophilia

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