Histomorphometry, Stereology of Germ Cells and Hormonal Alterations in Aluminum-Induced Testicular Toxicity of Adult Wistar Rat: The Ameliorative Effect of Composite Teas


Authors : Olawuyi T. S; Oluwasina O. O; Akinola B. K; Taiwo J. A

Volume/Issue : Volume 6 - 2021, Issue 12 - December

Google Scholar : http://bitly.ws/gu88

Scribd : https://bit.ly/3qp4LXa

This study aimed at the ameliorating effect of composite teas on aluminum-induced testicular-toxicity of adult male Wistar rats. Thirty adults male Wistar rats of average body weight of 100-180g, divided into 6 groups with Five (5) rats per group were used. Administration of aluminum chloride (AlCl3) was given for 2weeks, followed by composite tea administered orally for two (2) weeks. Group 1 received 0.15mg/kg of AlCl3, Group 2 (control) received feed pellets and distilled water. Groups 3, 4, 5 & 6 received 0.15mg/kg AlCl3 and 5mg/kg of composite tea respectively. Twenty-four hours after last administration, the animals were weighed, sedated with diethy-ether in a chamber, and blood was collected. The testes were excised and weighed. There were statistically significant alterations in the percentage of seminiferous tubular and seminiferous ductal diameter within the animals in all the groups (p<0.05). Significant changes in sperm parameters, hormone profiles and defective testicular morphology in Groups 1, 3, 4 when compared to the control group. However significant improvements were noticed in Group 6 after administration of composite tea, with restored sperm characteristics, restored hormonal assessments and preserved testicular structures. Conclusively, the ameliorating effect of the composite teas were revealed on aluminum-induced toxicity of adult Wistar rat.

Keywords : Male Infertilty, Histomorphometry, Composite Teas, Aluminium, Testicular Toxicity

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