Alcohol is a well-known damaging agent to the
gastric mucosa. Excessive alcohol ingestion is no doubt a
cause of human gastric ulcer. Coconut oil has been
reputed to possess antioxidant and anti-inflammatory
properties. It contains polyphenol and other very
important compound of medical importance. The aim of
this study is to evaluate the immunohistochemical effects
of Coconut Oil (CO) on gastric ulcer in wistar rats.
Twenty rats weighing 80-120g were divided into
four groups with five rats in each group. Induction of
gastric ulcer was done through oral administration after
the animals were fasted for 24hrs with 0.5ml of 90%
ethanol. Group A (control) received distilled water;
Group B received alcohol + Coconut oil; Group C
received alcohol + Omeprazole while Group D received
alcohol once daily. Animal treatment was for 4 weeks
after which they were sacrificed by cervical dislocation.
The stomach was harvested and blood samples obtained
by cardiac puncture. Samples were subjected to
immunohistological and biochemical analysis.
The results showed that there was gastric
ulceration in group D while groups B and C showed
marked mucosa repair on histological evaluation. There
was increased presence of Nrf2 in group D whereas it
was significantly reduced in groups B and C. There was
significant increase in MDA levels in group D while it
was significantly decreased in groups B and C when
compared with group A (P<0.05). There was significant
decrease in SOD levels in group D while it was
significantly increased in groups B compared with the
The results from this study showed that Coconut oil
has ameliorative potential on alcohol induced gastric
Gastric ulcer, Coconut Oil, Immunohistochemistry, Alcohol, Omeprazole.