Hepatoprotective Effect of Parkia Biglobosa Husk Methanol Extract Against Carbon Tetrachloride (CCL4) Induced Liver Damage in Albino Rats

Authors : Jude Nwaogu; Malam Sanusi Ahmed Jega; Shafiu Shehu Anka

Volume/Issue : Volume 7 - 2022, Issue 2 - February

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/37wF7sS

DOI : https://doi.org/10.5281/zenodo.6427469

Parkia biglobosahush extract have traditionally found useful in the treatment of liver and other different ailments. The present study was designed to assess the Hepatoprotective effects of Parkia biglobosa husk. The group of rats were orally administered with the Parkia biglobosahusk extract with and control group which received only distilled water. The liver function indicators, AST, ALT, Total bilirubin, direct bilirubin, protein and Albumin were measured using spectrophotometric method. Hepatoprotctive activity of methanolic extracts of Parkia biglobosa husk was carried out against (CCL4) induced liver damage. The extract was administered orally at doses of 50,100,150 and 200mg/kg-1 body weight once daily. Hepatoprotective activity was measured based on biochemical parameters. Significantly (0.05) increase level of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase(ALP), total bilirubin(TB) and direct bilirubin(DB) were seeing rats induced with CCL4.the decrease significantly level of protein and albumin were seeing in rats treated with CCL4.While normal levels were restored in rats treated with standard drug(silymarin 100mg/kg) and rats treated with the extract. The result is suggested that the extracts have Hepatoprotective effects.

Keywords : Hepatoprotective, Parkia Biglobosa Husk, Carbon Tetrachloride, Transaminase And Alkaline Phosphates, Total Bilirubin, Direct Bilirubin,Albumin And Total Protein.


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