Authors : Akkal Dev Mishra

Volume/Issue : Volume 8 - 2023, Issue 12 - December

Google Scholar : http://tinyurl.com/4tb2vy2d

Scribd : http://tinyurl.com/m457zpmb

DOI : https://doi.org/10.5281/zenodo.10437710

Abstract : Chemical and pharmacological properties of five- membered heterocycles have gained interest in synthetic chemistry recently. They cover a wider spectrum of antimicrobial activities. Among them, Oxazoles have been proved as potent chemotherapeutics. A series of novel amido-oxazoles are synthesized from carbonyls, carboxylic acids and isocyanides under microwave irradiations in solid-support of alumina. Microwave-coupled organic synthesis has been proved as an efficient and eco-friendly tool in modern synthetic chemistry. It avoids the usage of hazardous chemicals in various steps of synthesis and accompanied by very short reaction time, high yield with extra degree of purity of the products and easy work-up. Synthesis of amido- oxazoles involves condensation of the reactants followed by cyclisation. A Comparative study has been made between conventional and microwave synthetic routes. The compounds have been found to possess moderate to excellent antifungal and antibacterial potentials.

Keywords : Microwave, solid support, heterocycles, chemotherapeutics, antimicrobial activities.