Authors : Akhilesh Chandra Yadav; Amit Kumar Tyagi; Tanzin Lamo; Adithya A. G.; Mihir Agarwal

Volume/Issue : Volume 11 - 2026, Issue 10 - October

---

Google Scholar : https://tinyurl.com/ybnn25su

DOI : https://doi.org/10.38124/ijisrt/26Oct018

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

---

Abstract : Giant cell tumor (GCT) of the temporal bone is a rare, locally aggressive neoplasm. Its co-occurrence with secondary aneurysmal bone cyst (ABC)-like changes and extensive extradural extension into the middle cranial fossa (MCF) is exceptionally rare. A 24-year-old female presented with progressive left-sided conductive hearing loss and a slowly enlarging mass in the external auditory canal. High-resolution computed tomography (HRCT) revealed an expansile, erosive lesion involving the left temporal bone with extension into the external auditory canal, middle ear cavity, and mastoid air cells.

Keywords : Giant Cell Tumor, Temporal Bone, Middle Cranial Fossa, Skull Base Tumor, Petrosectomy, Aneurysmal Bone Cyst, External Auditory Canal

References :

1. Kaya İ, et al. Giant cell tumor of the temporal bone and skull base: a case report. J Int Adv Otol. 2018;14(1):148–151. doi:10.5152/iao.2017.3779
2. Iizuka T, Furukawa M, Ishii H, et al. Giant cell tumor of the temporal bone with direct invasion into the middle ear and skull base: a case report. Case Rep Otolaryngol. 2012;2012:690148. doi:10.1155/2012/690148
3. Chidambaram B, Santosh V, Balasubramaniam V. Aneurysmal bone cyst of the temporal bone. Childs Nerv Syst. 2001;17(7):411–414. DOI 10.1007/s003810000428.
4. Modkovski R, Elliott R, Rubin B, Zagzag D, Jafar J, Mikolaenko I. Giant cell tumor of the occipital bone and secondary aneurysmal bone cyst: case report and review of the literature. Internet J Neurosurg. 2009;7(2). doi:10.5580/641
5. Kommu VR, Murthy SS, Sudhir R, Kumari SC. Temporal bone giant-cell tumor with secondary aneurysmal bone cyst: a rare case report and review of the literature. Int J Neurooncol. 2020;3(1):60–62. doi:10.4103/ijno.ijno_1_20
6. Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA, Matcuk GR Jr. Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 2013;33(1):197–211. https://doi.org/10.1148/rg.331125089.
7. Gunterberg B, Kindblom LG, Laurin S. Giant-cell tumor of bone and aneurysmal bone cyst: a correlated histologic and angiographic study. Skeletal Radiol. 1977;2:65–74. https://doi.org/10.1007/BF00360984.
8. Bertoni F, Unni KK, Beabout JW, Ebersold MJ. Giant cell tumor of the skull. Cancer. 1992 Sep 1;70(5):1124-32. doi: 10.1002/1097-0142(19920901)70:5<1124::aid-cncr2820700517>3.0.co;2-p.
9. Anchan C. Giant cell tumor of bone with secondary aneurysmal bone cyst. Int J Shoulder Surg. 2008 Jul;2(3):68. doi: 10.4103/0973-6042.42582.
10. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, et al. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010;11(3):275–280. doi:10.1016/S1470-2045(10)70010-3