Authors :
DR K. RAGHU NATHA REDDY; DR K. VENKATA SUDHAKAR NAIK; DR D. LAKSHMI KANTH; DR. Y.V.SATYANARAYANA
Volume/Issue :
Volume 8 - 2023, Issue 1 - January
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3YvkO4t
DOI :
https://doi.org/10.5281/zenodo.7637993
Abstract :
Giant cell tumor (GCT) is usually a benign
tumor of the bone which arises from the metaphysis
area and may typically extends into the epiphysis of the
long bones. These are neoplasms arising from
mesenchymal stromal cells and shows varied
manifestations. GCT is considered to be of benign
nature but 3% of giant cell tumors of bone are
primarily malignant in nature or will undergo
malignant transformation and metastasize to lung and
other areas. Pathological fracture rates range from 9%
to 30% among patients with GCTs of the bone at the
time of initial presentation. Due to the lack of definite
clinical, radiological, or histological parameters that
can accurately predict the progression of the disease,
treating this tumour remains a difficult problem.
Patients who present with a pathological fracture are
frequently thought to have a more aggressive form of
disease, which increases their chance of local recurrence
and worsens their prognosis. We consider it essential to
share a case of a distal femoral GCT with a pathological
fracture that was treated by enbloc excision and
reconstruction with megaprosthesis with good
functional outcome.
Keywords :
GCT, Distal femur, Pathological fracture, Megaprosthesis.
Giant cell tumor (GCT) is usually a benign
tumor of the bone which arises from the metaphysis
area and may typically extends into the epiphysis of the
long bones. These are neoplasms arising from
mesenchymal stromal cells and shows varied
manifestations. GCT is considered to be of benign
nature but 3% of giant cell tumors of bone are
primarily malignant in nature or will undergo
malignant transformation and metastasize to lung and
other areas. Pathological fracture rates range from 9%
to 30% among patients with GCTs of the bone at the
time of initial presentation. Due to the lack of definite
clinical, radiological, or histological parameters that
can accurately predict the progression of the disease,
treating this tumour remains a difficult problem.
Patients who present with a pathological fracture are
frequently thought to have a more aggressive form of
disease, which increases their chance of local recurrence
and worsens their prognosis. We consider it essential to
share a case of a distal femoral GCT with a pathological
fracture that was treated by enbloc excision and
reconstruction with megaprosthesis with good
functional outcome.
Keywords :
GCT, Distal femur, Pathological fracture, Megaprosthesis.
