Authors :
Samran Shahid; Satya Sai Abhiram Oggu; Hyojoo Kim
Volume/Issue :
Volume 5 - 2020, Issue 12 - December
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3hUY8pV
Abstract :
The HFE gene is present in the genome of
various organisms, including Homo sapiens and
functions to regulate the amount of iron in the body.
With speciation, HFE gene has evolved in the various
organisms but organisms having the common ancestry
still have the HFE protein structure similar to the
ancestral homologues. This has been proved and the
applications to this have been extrapolated in this paper.
This paper has therefore hypothesized a likely source of
the transgenic HFE gene for gene therapy and other
therapies that are under development. Besides the
hypothesis of transgenic HFE source, the paper also
shows the relation of Homo sapiens with its Primate
ancestors such as Gorilla gorilla and Pan troglodytes.
The approach to the extrapolation of results was
using the Basic Local Alignment Sequence Tool
(BLAST) of the Homo sapiens HFE gene (NM_000410.4
Homo sapiens homeostatic iron regulator (HFE),
transcript variant 1, mRNA) and then Pairwise
alignment of the Closest genes to the Homo sapiens HFE
gene. To further strengthen the claim, the Homo sapiens
HFE protein was aligned with that of the closest genes
that were found using BLAST. The results found that
the Pan troglodytes HFE gene was close to 99.35% in
identity to the Homo sapiens HFE, whereas Pan
troglodytes protein had a 100% match to that of Homo
sapiens HFE protein.
Thus the chimpanzee HFE gene can act as a source
for the transgenic genes for curing the Classic, Type-I
hemochromatosis, wherein the HFE protein synthesized
by the body is dysfunctional to regulate the Iron in the
body as Iron sensing complex is rendered dysfunctional
by the malformed HFE protein which leads to the high
amount of iron in the body which causes various
problems such as diabetes, liver cirrhosis and etc in the
long run.
Keywords :
Hemochromatosis, HFE Gene, HFE Protein, HFE Trans-Genesis.
The HFE gene is present in the genome of
various organisms, including Homo sapiens and
functions to regulate the amount of iron in the body.
With speciation, HFE gene has evolved in the various
organisms but organisms having the common ancestry
still have the HFE protein structure similar to the
ancestral homologues. This has been proved and the
applications to this have been extrapolated in this paper.
This paper has therefore hypothesized a likely source of
the transgenic HFE gene for gene therapy and other
therapies that are under development. Besides the
hypothesis of transgenic HFE source, the paper also
shows the relation of Homo sapiens with its Primate
ancestors such as Gorilla gorilla and Pan troglodytes.
The approach to the extrapolation of results was
using the Basic Local Alignment Sequence Tool
(BLAST) of the Homo sapiens HFE gene (NM_000410.4
Homo sapiens homeostatic iron regulator (HFE),
transcript variant 1, mRNA) and then Pairwise
alignment of the Closest genes to the Homo sapiens HFE
gene. To further strengthen the claim, the Homo sapiens
HFE protein was aligned with that of the closest genes
that were found using BLAST. The results found that
the Pan troglodytes HFE gene was close to 99.35% in
identity to the Homo sapiens HFE, whereas Pan
troglodytes protein had a 100% match to that of Homo
sapiens HFE protein.
Thus the chimpanzee HFE gene can act as a source
for the transgenic genes for curing the Classic, Type-I
hemochromatosis, wherein the HFE protein synthesized
by the body is dysfunctional to regulate the Iron in the
body as Iron sensing complex is rendered dysfunctional
by the malformed HFE protein which leads to the high
amount of iron in the body which causes various
problems such as diabetes, liver cirrhosis and etc in the
long run.
Keywords :
Hemochromatosis, HFE Gene, HFE Protein, HFE Trans-Genesis.
