Authors : Archita Tiwari; Vishwanath Dubey; Shilpi Mishra; Seema Singh; Sandeep Yadav; Devendra Kumar Mishra; Savita Upadhyay
Volume/Issue : Volume 7 - 2022, Issue 5 - May
Google Scholar : https://bit.ly/3IIfn9N
Scribd : https://bit.ly/3A7ITF2
DOI : https://doi.org/10.5281/zenodo.6760060
This review summarizes the advancement in
liquid chromatography-mass spectrometry (LC-MS).
Liquid Chromatography and Mass Spectrometer is a
hyphenated technique of separation of compounds. over
the past years, the combination 0f high-performance
liquid chromatography and mass spectrometry (LC-MS)
has been used which has a remarkable effect on drug
research and development. LC-MS played a vital role in
the assessment and interpretation of bioavailability and
bioequivalence. This article reviews the principle of
LCMS analysis using liquid chromatography and mass
spectrometry. Mass spectrometry comprises 3 important
parts that are ionization source, mass analyzer, and
detector.
Keywords : spectrometry; bioequivalence; chromatography; mass analyzer; bioavailability.
