General Instrumentation of LC-MS Technique and their Recent Applications


Authors : Archita Tiwari; Vishwanath Dubey; Shilpi Mishra; Seema Singh; Sandeep Yadav; Devendra Kumar Mishra; Savita Upadhyay

Volume/Issue : Volume 7 - 2022, Issue 5 - May

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3A7ITF2

DOI : https://doi.org/10.5281/zenodo.6760060

This review summarizes the advancement in liquid chromatography-mass spectrometry (LC-MS). Liquid Chromatography and Mass Spectrometer is a hyphenated technique of separation of compounds. over the past years, the combination 0f high-performance liquid chromatography and mass spectrometry (LC-MS) has been used which has a remarkable effect on drug research and development. LC-MS played a vital role in the assessment and interpretation of bioavailability and bioequivalence. This article reviews the principle of LCMS analysis using liquid chromatography and mass spectrometry. Mass spectrometry comprises 3 important parts that are ionization source, mass analyzer, and detector.

Keywords : spectrometry; bioequivalence; chromatography; mass analyzer; bioavailability.

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