Authors : Podili Chandrakala; K. Sai Rajesh; Thalla Sai Niharika; M. Arul Arasan; V. G. Gayathri; Nethakara Naveena

Volume/Issue : Volume 11 - 2026, Issue 10 - October

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Google Scholar : https://tinyurl.com/ysu59f9p

DOI : https://doi.org/10.38124/ijisrt/26Oct1137

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

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Abstract : The present aim of the work was to formulate and evaluate curcumin topical Emulgel for transdermal drug delivery. To incorporate curcumin in Emulgel and to entrap the drug by carbopol polymer. Topical preparations are used for localized effect at the site of their application by virtue of drug penetration into the underlying the layers of the skin or mucus membrane. This avoids the first pass metabolism. Emulgels are the best for controlled drug release systems. Curcumin emulgel formulations were formulated and characterized for standardization, drug content, pH, viscosity, physical parameters, spreading coefficient, swelling index, in-vitro diffusion studies.

Keywords : Curcumin, Entrap, Transdermal, Emulgel, Controlled Drug Release.

References :

1. Rieger M, Lachman L, Lieberman H, Kanig J; The Theory and Practice of Industrial Pharmacy: 3rd ed. PA Lea and Febiger: Philadelphia: 1986, 502-33.
2. Khullar R, Saini S, Seth N, Rana A; Emulgels: A surrogate approach for topically used hydrophobic drugs. International Journal of Pharmacy and Biological Sciences. 2011, 1:117-28.
3. Sean C Sweetman, Martindale the Complete Drug Reference: the Pharmaceutical Press, 2009, 117-8.
4. Klaus Florey; Analytical Profile of Drug Substance: Elsevier, 15:511-30
5. Joshi B, Singh G, Rana AC, Saini S, Singla V. Emulgel: A comprehensive review on the recent advances in topical drug delivery. Int Res J Pharm 2011; 2(11): 66-70.
6. Dadwal M. Emulgel: A novel approach to topical drug delivery. Int J Pharm Bio Sci,  jan, 2013; 4(1): 847-56.
7. Rachit K, Saini S, Seth N, Rana AC. Emulgel: A surrogate apporoach for topically used hydrophobic drug. Int J Pharm Bio Sci, july-sept, 2011; 1(3): 117-28.
8. Kullar R, Saini S, Steth N, Rana AC, Emulgel A surrogate approach for topical used hydrophobic drugs. Int J pharma biol sci, 2011; 117-28.
9. Mohamed MI. Topical Emugel composition comprising diclofenac sodium. AAPS J.,2004; 6(3): 26.
10. Prajapati M., Patel M., Patel K., Patel N.. Emulgels: A novel approach to topical drug delivery. International Journal of Universal Pharmacy and Bio Sciences 2(1) (2013),pp.134-148.
11. Sngla,V., Sani,S., JosephI,B. and Rana,A.C. Emulgel: A new platform for topical drug delivery. International Journal of Pharma and Bio Sciences 3 (2012),pp.485-498.
12. Surver and F.A. Davis, Bioavailability and Bioequivalence, In: K.A Walter (eds.), Dermatological and Transdermal Formulation, Marcel Dekker, New York, 2002, pp. 323- 327,403
13. Ansel HC, Allen LV Jr., Popovich NG. Pharmaceutical Dosage Forms and Drug Delivery Systems. New York Lippincott Williams and Wilkins 7th ed.; 1999.
14. Rieger MM, Lachman L, Lieberman HA, Kanig JL (1986) The theory and Practice of Industrial Pharmacy.
15. Panwar AS, Upadhyay N, Bairagi M, Gujar S, DarwhekarGN, Jain DK. Emulgel: A Review. Asian Journal of Pharmacy and Life Science 2011; 1(3): 333-34
16. Jain A, Gautam SP, Gupta, Jain S. Development and characterization of  Ketoconazole emulgel for topical drug delivery. Der Pharmacia Sinica. 2010; 1(3):221231
17. Sharma S. Topical preparations are used for the localized effects at the site of theirapplication by virtue of drug penetration into the underlying layers of skin or mucousmembranes. Pharmaceutical reviews 2008; 6:1.
18. Laithy HM. and El shaboury KMF. The development of CutinaLipogels and gel microemulsion for topical administration of fluconazole. Ame Pharm Sci. PharmSciTech. 2003; 3:10 25.
19. Jain A, Deveda P, Vyas N, Chauhan J et al. Development Of Antifungal Emulsion Based Gel ForTopical Fungal Infection(S). IJPRD 2011; 2(12).
20. Bruton L, Keith P, Blumenthal D, Buxton Z. Goodman & Gillman’s Manual of Pharmacology &Therapeutics. Mc Graw’s Hill. 2008. pp.1086-1094.
21. Surver and F.A. Davis, (2002), Bioavailability and Bioequivaance. Dermatological and Transdermal Formulation, Marcal Dekker, New York, 403, 323- 327.
22. Sharma S, (2008), Topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes. Pharmaceutical reviews, 6(1).
23. Laithy HM. and El shaboury KMF, (2003), The development of CutinaLipogelsandgel microemulsion for topical administration of fluconazole. PharmSciTech. 3, 10-25.
24. Kuller R, Saini S, Seth N, Rana AC, (2011), Emulgel: A surrogate approach fortopical used hydrophobic drugs. Int J Pharm Bio Sci, 1:(3), 117-128.
25. Nayak B S, Nayak U K , Patro and Balakrishna Bioadhesive Vaginal gel for prolomged release of Metronidazole Formulation, Development, Characterisatiopn and Comparitive Study with Marketed Formulation. International Journal of Pharmaceutical Sciences and Techonology 2009; 2(1) : 30 – s 36.
26. Basha BN , Prakasam K, Goli D. Formulation and evaluation of Gel containing Fluconazole- Antifungal Agent. Int J Drug Dev Res 2011; 3(4):119.
27. Bachhav Y, Patravale V; Microemulsion based vaginal gel of fluconazole: Formulation, in vitro and in-vivo evaluation. International Journal of Pharmaceutics. 2009, 365: 175–9.
28. Birandar S, Paradkar A Mahandik K In vitro Evaluation of Topical Gel Prepared using Silk Fibroin at Different concentrations of Gel Accelerating agent- Glycerol. International Journal of Pharmaceutical and Biological Sciences 2011; 2 (1) : 646 – 660.
29. Chandira RM Et Al. Design, Development and formulation of anti-acne Dermatological gel. Journal of Chemical and Pharmaceutical Research 2010; 2 (1) : 401 – 414.
30. Chaudhari P, Ajab A,Malpure P, Kolsure P, SanapD,Development and in-vitro evaluation of thermo reversible nasalgel formulations of Rizatriptan benzoate, Indian J.PharmEdu.Res., 2009; 43: 55-62.