Authors : Dr. Shweta Shivshankar Suman; Rupesh Pingale; Wilyana Stephen Colaco; Janhavi Hanuman Patil; Sudip Parag Shinde; Akshay Bajabhau Bhandari

Volume/Issue : Volume 11 - 2026, Issue 8 - August

Google Scholar : https://tinyurl.com/mt9zs8kn

Scribd : https://tinyurl.com/494texjj

DOI : https://doi.org/10.38124/ijisrt/26aug377

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Background: Alopecia areata (AA) is a T-lymphocyte-mediated autoimmune disorder causing non-scarring patchy hair loss, affecting approximately 2% of the global population.[1,2,4] Conventional therapies — corticosteroids, immunosuppressants, JAK inhibitors — carry adverse effects and high relapse rates. Polyherbal cosmeceuticals offer a safer, multi-mechanistic alternative.  Methods: Five authenticated herbal drugs — Bhringraj (Eclipta alba), Neem (Azadirachta indica), Manjistha (Rubia cordifolia), Green Tea (Camellia sinensis), and Brahmi (Bacopa monnieri) — were extracted via Soxhlet (ethanol:water, 50:50 v/v). Four O/W emulsion-based serum batches (F1–F4) were evaluated for pH, viscosity, spreadability, drug content, antioxidant activity (H₂O₂ scavenging), and accelerated stability (ICH Q1A).

Keywords : Alopecia Areata, Polyherbal Serum, Eclipta Alba, Azadirachta Indica, Rubia Cordifolia, Camellia Sinensis, Bacopa Monnieri, Emulsion, EGCG, 5α-Reductase.

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