Formulation and Optimisation of Mucoadhesive Microsphere of H2 Antagonist Drug


Authors : Akshay S. Raut; Dr. Sachin J. Dighade; Esha S. Rithe; Reema R. Mangwani; Ashish L. Pohane; Samiksha S. Bhamburkar

Volume/Issue : Volume 10 - 2025, Issue 3 - March

Google Scholar : https://tinyurl.com/3knyyjfp

Scribd : https://tinyurl.com/ysw5j5ae

DOI : https://doi.org/10.38124/ijisrt/25mar523

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Abstract : The administration of pharmaceuticals to patients is the primary focus of a drug delivery system, which aims to maximize therapeutic benefits while reducing hazards. Drugs may be administered in various ways, from the digestive tract to the skin and veins. One novel approach developed to assure sustained, steady medication release is gastro-retentive drug delivery systems (GRDDSs). Mucoadhesive drug delivery devices are a top choice for medications with low oral bioavailability. Nizatidine hydrochloride is an H2 receptor antagonist, and its incorporation into mucoadhesive microspheres has been a primary focus in recent years. The pharmacological effect of the medicine is improved, and its release is prolonged using this method. This formulation uses sodium alginate dissolved in distilled water, carbopol solution, and Nizatidine in different amounts to accomplish ionotropic gelation. After the mixture is well emulsified, a calcium chloride solution is added. The number of microspheres adhering to tissue was counted at the end of 30 minutes, 1h, and hourly intervals up to 12 hours. Microspheres' potential mucoadhesive characteristics are shown by in vitro adhesion tests after careful preparation. The effectiveness of encapsulation and assessments of pharmaceutical content over predetermined batches (T1-T9) testify to the successful encapsulation of medications inside the delivery system, which serves as validation. To better treat disorders like peptic ulcers, this research highlights the promise of mucoadhesive microspheres as a regulated medication delivery route for Nizatidine.

Keywords : Nizatidine, Ionotropic Gelation Technique, Microspheres, Sustained Release, Carbopol.

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The administration of pharmaceuticals to patients is the primary focus of a drug delivery system, which aims to maximize therapeutic benefits while reducing hazards. Drugs may be administered in various ways, from the digestive tract to the skin and veins. One novel approach developed to assure sustained, steady medication release is gastro-retentive drug delivery systems (GRDDSs). Mucoadhesive drug delivery devices are a top choice for medications with low oral bioavailability. Nizatidine hydrochloride is an H2 receptor antagonist, and its incorporation into mucoadhesive microspheres has been a primary focus in recent years. The pharmacological effect of the medicine is improved, and its release is prolonged using this method. This formulation uses sodium alginate dissolved in distilled water, carbopol solution, and Nizatidine in different amounts to accomplish ionotropic gelation. After the mixture is well emulsified, a calcium chloride solution is added. The number of microspheres adhering to tissue was counted at the end of 30 minutes, 1h, and hourly intervals up to 12 hours. Microspheres' potential mucoadhesive characteristics are shown by in vitro adhesion tests after careful preparation. The effectiveness of encapsulation and assessments of pharmaceutical content over predetermined batches (T1-T9) testify to the successful encapsulation of medications inside the delivery system, which serves as validation. To better treat disorders like peptic ulcers, this research highlights the promise of mucoadhesive microspheres as a regulated medication delivery route for Nizatidine.

Keywords : Nizatidine, Ionotropic Gelation Technique, Microspheres, Sustained Release, Carbopol.

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